ReviewF1000prime reports2015
Advances in understanding Giardia: determinants and mechanisms of chronic sequelae.
Review in F1000prime reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 151 citations in OpenAlex.
- Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Spatial and Molecular Epidemiology of Giardia intestinalis Deep in the Amazon, Brazil.PloS one · 2016Trial
- Pathogenicity and virulence ofVirulence · 2026Review
- Seasonally Varying Effects of Improved Water, Sanitation, and Handwashing Interventions onOpen forum infectious diseases · 2026Article
- Article
- Giardiasis and Bupropion-Associated Gastrointestinal Symptoms in a Returning Traveler: A Diagnostic Challenge Case Report.Reports (MDPI) · 2026Article
- T cell exhaustion inParasite epidemiology and control · 2026Review
- The differential roles of Giardia duodenalis-secreted tenascins in inducing intestinal epithelial cell apoptosis and the attributed EGFR-STAT3 axis regulation.PLoS neglected tropical diseases · 2026Article
- Household deprivation score demonstrates graded association with intestinal parasitic infections among schoolchildren in a conflict-affected setting: a cross-sectional study.Frontiers in public health · 2026Article
- Seasonally varying effects of improved water, sanitation and handwashing interventions on Giardia infection in Bangladesh.medRxiv : the preprint server for health sciences · 2025Article
- Prevalence of Helicobacter pylori and intestinal parasitic coinfections among patients with gastrointestinal complaints in a Rwandan Teaching Hospital.BMC infectious diseases · 2025Article
- Human Giardiasis in Ghana - A Scoping Review of Studies From 2004 to 2024.Health science reports · 2025Article
- Prevalence and infestation dynamics of intestinal protozoa infections (cryptosporidiosis, giardiasis and eimeriosis) among calves in dairy farms of Kazakhstan.Frontiers in veterinary science · 2025Article
- Molecular characterization and risk analysis of Giardia duodenalis assemblages in corticosteroid-treated and non-treated patients in Ismailia, Arab Republic of Egypt.Gut pathogens · 2024Article
- The Therapeutic Effects of Lycopene Against Experimental Giardiasis in Mice.Food science & nutrition · 2024Article
- The Influence of the ProtozoanInternational journal of molecular sciences · 2024Review
- Current Understanding ofCurrent tropical medicine reports · 2024Article
- Childhood Intestinal Parasitic Reinfection, Sanitation and Hygiene Practice in Eastern Ethiopia: Case Control Study.Infection and drug resistance · 2024Article
- Microscopy detection and molecular characterisation ofFrontiers in public health · 2024Article
- Symptomatic and asymptomatic enteric protozoan parasitic infection and their association with subsequent growth parameters in under five children in South Asia and sub-Saharan Africa.PLoS neglected tropical diseases · 2023Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Giardia lamblia is a flagellated protozoan that is the most common cause of intestinal parasitic infection in children living in resource-limited settings. The pathogenicity of Giardia has been debated since the parasite was first identified, and clinical outcomes vary across studies. Among recent perplexing findings are diametrically opposed associations between Giardia and acute versus persistent diarrhea and a poorly understood potential for long-term sequelae, including impaired child growth and cognitive development. The mechanisms driving these protean clinical outcomes remain elusive, but recent advances suggest that variability in Giardia strains, host nutritional status, the composition of microbiota, co-infecting enteropathogens, host genetically determined mucosal immune responses, and immune modulation by Giardia are all relevant factors influencing disease manifestations after Giardia infection.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.