Inhibitory effect of 5F on development of lung cancer in A/J mice.

Hua Ye, Xiaoqing Yang, Kefeng Wu, Li Li, Yingnian Lv, Yi Liu, Xuebao Zheng

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 93% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

The High Content ofFoods (Basel, Switzerland) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hua YeGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Xiaoqing YangGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Kefeng WuGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Li LiGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Yingnian LvGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Yi LiuGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Xuebao ZhengGuangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College Zhanjiang 524023, Guangdong Province, China.

Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the study is to investigate the effect of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) on the model of induced A/J mice lung cancer in A/J mice. The expressions of tumor-related molecules including P65 and Bcl-2 at protein level were examined using the immunohistochemical method (IHC). Side effects of 5F were also monitored. The results indicated that 5F significantly suppressed the development of B[a]P and NNK-induced lung cancer in vivo by facilitating cell apoptosis with minimal side effects. Compared to the expressions of P65 and Bcl-2 in model group, the levels were strongly attenuated both in blank and 5F injection groups. Moreover, P65 and Bcl-2 levels varied among different groups receiving 5F treatment. The expressions of P65 and Bcl-2 were much lower in groups receiving high-concentration 5F treatment than those with low-concentration 5F injection. Findings revealed that 5F inhibited the pathogenesis of lung cancer through accelerating apoptosis in a dose-dependent manner.

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisBenzo(a)pyreneDiterpenes, KauraneDose-Response Relationship, DrugLung NeoplasmsMiceNitrosaminesProto-Oncogene Proteins c-bcl-2Time FactorsTranscription Factor RelA4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneAntineoplastic Agents, PhytogenicBcl2 protein, mouseBenzo(a)pyreneDiterpenes, Kauraneent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acidNitrosaminesProto-Oncogene Proteins c-bcl-2Rela protein, mouseTranscription Factor RelA5FA/J miceinduced lung cancersuppression

Identifiers

PMID26097604

PMCPMC4466991

OpenAlexW2192749166

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.