ArticleInternational journal of clinical and experimental pathology2015
Whether Alzheimer's diseases related genes also differently express in the hippocampus of Ts65Dn mice?
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- The human intelligence evolved from proximalQuantitative biology (Beijing, China) · 2025Article
- Rodent Modeling of Alzheimer's Disease in Down Syndrome:Frontiers in neuroscience · 2022Review
- Systematic Analysis and Identification of Dysregulated Panel lncRNAs Contributing to Poor Prognosis in Head-Neck Cancer.Frontiers in oncology · 2021Article
- Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimer's Disease.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDown syndrome is a condition which extra genetic material causes delays in child development, both mentally and physically. Strengthening the study of the neural defects of DS is of great significance.
methodsTs65Dn mice were used in this study. We removed the brain and isolated their hippocampus. We customized 54 genes in one PCR arrays, included some important genes related to Alzheimer's disease. The expression of genes were detected by RT-PCR.
resultsPCR arrays contained 54 genes related to Alzheimer's disease. After real-time PCR, three genes (Nae1, APP and Mapt) expressed differently in the hippocampus of Ts65Dn, compared with the normal mice. Nae1 was decreased significantly, while APP and Mapt were increased obviously. The levels of fold-changes of Nae1, APP and Mapt were 86.19, 4.49 and 2.89 respectively. Significantly different levels of expression were found in the Ts65Dn mice compared with the normal control group (P=0.00 for Nae1, P=0.02 for APP, P=0.01 for Mapt respectively).
conclusionsThere are differential expressed genes in the hippocampus of Ts65Dn mice that may be closely related to Alzheimer's disease. PCR array technology was used in the screening and identification of these genes.
Indexed as
Identifiers
26097601PMC4466988W992808456What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.