ArticleInternational journal of clinical and experimental pathology2015
Vascular invasion as an independent predictor of poor prognosis in nonmetastatic gastric cancer after curative resection.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Dual-layer detector spectral CT-derived extracellular volume fraction combined with clinical parameters for predicting lymphovascular and perineural invasion in gastric cancer.Abdominal radiology (New York) · 2026Article
- Survival Outcomes of Patients With Colorectal Cancer After Primary Surgery: A Population-Based Study in Hainan, China.Cancer medicine · 2026Article
- Comparison of 2D and 3D measured iodine concentration of gastric adenocarcinoma on spectral-CT and their relationship with perineural invasion.BMC medical imaging · 2025Article
- Prognostic Factors and Survival Analysis in Undifferentiated Gastric Carcinoma.Journal of clinical practice and research · 2024Article
- The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer.International journal of molecular sciences · 2023Review
- Identification of intestinal microbiome associated with lymph-vascular invasion in colorectal cancer patients and predictive label construction.Frontiers in cellular and infection microbiology · 2023Article
- A computed tomography-based preoperative risk scoring system to distinguish lymphoepithelioma-like gastric carcinoma from non-lymphoepithelioma-like gastric carcinoma.Frontiers in oncology · 2022Article
- Article
- Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer.World journal of gastrointestinal oncology · 2020Article
- ASO Author Reflections: Gastric Cancer Staging: More than Just TNM?Annals of surgical oncology · 2020Article
- Prognostic Significance of Lymphatic, Venous and Perineural Invasion After Neoadjuvant Chemotherapy in Patients with Gastric Adenocarcinoma.Annals of surgical oncology · 2020Article
- Role of Conversion Surgery for Unresectable Pancreatic Cancer After Long-Term Chemotherapy.World journal of surgery · 2020Article
- Long Intergenic Non-Protein Coding RNA 1089 Suppresses Cell Proliferation and Metastasis in Gastric Cancer by Regulating miRNA-27a-3p/Epithelial-Mesenchymal Transition (EMT) Axis.Cancer management and research · 2020Article
- Clinical significance of serum total oxidant/antioxidant status in patients with operable and advanced gastric cancer.OncoTargets and therapy · 2018Article
- Significance of preoperative ischemia- modified albumin in operable and advanced gastric cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Application of CT texture analysis in predicting histopathological characteristics of gastric cancers.European radiology · 2017Article
- Article
- Methylation Levels of LINE-1 As a Useful Marker for Venous Invasion in Both FFPE and Frozen Tumor Tissues of Gastric Cancer.Molecules and cells · 2017Article
- Seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up.World journal of gastroenterology · 2016Review
- A Novel Nomogram for Individually Predicting of Vascular Invasion in Gastric Cancer.Technology in cancer research & treatmentArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognostic significance of vascular invasion (VI) in nonmetastatic gastric cancer (GC) remains a matter of controversy. The purpose of this study was to assess the impact of VI on survival in this group of GC patients. We enrolled 361 GC patients without metastasis who underwent curative gastrectomy between 1996 and 2009 in Sun Yat-sen University Cancer Center. A retrospective analysis of the clinicopathological data was performed, focusing on the impact of VI detected by routine H&E staining on disease-free survival (DFS) and cancer-specific survival (CSS). The presence of VI was detected in 13.9% of our cohort. The VI status was significantly correlated with the tumor size, infiltration depth, and TNM stage (P < 0.05). Patients with VI showed significantly lower DFS and CSS compared with patients without VI (P < 0.0001 for both). The subgroup analysis indicated that the presence of VI was a negative predictor of DFS in all TNM stages and a predictor of lower CSS only in stage I (P < 0.05 for all). A multivariate Cox proportional analysis identified VI as an independent predictor of CSS (P = 0.022). The presence of VI is a risk factor for recurrence and an independent predictor of poor survival in nonmetastatic GC after curative resection. The VI status should be considered to stratify with this group of GC patients for adjuvant treatment and more effective follow-up protocol.
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