ArticleInternational journal of clinical and experimental pathology2015
Upregulated expression of N-methyl-D-aspartate receptor 1 and nitric oxide synthase during form-deprivation myopia in guinea pigs.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- High-Color-Temperature Lighting Is Associated With Activation of MAPK/ERK-nNOS Signaling and MMP-2-Related Pathways in Ocular Tissues.Investigative ophthalmology & visual science · 2026Article
- Review
- Role of BDNF in form-deprivation myopia progression in guinea pigs.Frontiers in immunology · 2026Article
- The potential role of amino acids in myopia: inspiration from metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Nitric oxide: an old drug but with new horizons in ophthalmology-a narrative review.Annals of translational medicine · 2023Review
- Effects of inflammation on myopia: evidence and potential mechanisms.Frontiers in immunology · 2023Review
- Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.Frontiers in physiology · 2020Article
- The involvement of the mGluR5-mediated JNK signaling pathway in rats with diabetic retinopathy.International ophthalmology · 2019Article
- Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth.PLoS biology · 2018Article
- Citicoline retards myopia progression following form deprivation in guinea pigs.Experimental biology and medicine (Maywood, N.J.) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the expression of N-methyl-D-aspartate receptor 1 (NMDAR1) and neuronal constitutive nitric oxide synthase (ncNOS) during form-deprivation myopia (FDM). FDM models were established in guinea pigs with facemasks. NMDAR1 expression in the retina was detected by immunohistochemistry and Western blot analysis. ncNOS mRNA expression was examined by in situ hybridization. cGMP content was measured by radioimmunoassay. In control group, NMDAR1 and ncNOS were expressed in binocular retinas, and there was no significant difference in NMDAR1 and ncNOS expression and cGMP content between the two eyes. However, NMDAR1 and ncNOS expression and cGMP content in the retina of FDM eyes were significantly higher than that of contralateral untreated eyes. Furthermore, ncNOS mRNA level and cGMP content was highly correlated. In conclusion, FDM upregulates the expression of NMDAR1 and ncNOS and increases cGMP content in the retina. NMDAR1/NO-cGMP pathway may contribute to abnormal visual signals during myopic progression.
Indexed as
Identifiers
26097564PMC4466951W787054054What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.