ArticleInternational journal of clinical and experimental pathology2015
Expression of androgen receptor in coronary artery in the cases of sudden coronary death.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
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- CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion.Frontiers in immunology · 2022Article
- Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice.Frontiers in molecular neuroscience · 2022Article
- Association of free androgen index and sex hormone-binding globulin and left ventricular hypertrophy in postmenopausal hypertensive women.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Anabolic-androgenic steroids and cardiovascular risk.Chinese medical journal · 2019Review
- Testosterone, myocardial function, and mortality.Heart failure reviews · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the expression of androgen receptor (AR) in the cases of sudden death caused by coronary heart disease (CHD) and relationship between AR and sudden coronary death (SCD) to explore the mechanism of the development of coronary atherosclerosis and provide references for the prevent and treatment of CHD and medicolegal identification of SCD. 53 cases selected from the autopsied cases in our department from 2011 to 2012 were divided into 3 groups: 18 case of SCD, including 11 males and 7 females, as experimental group, another 18 cases, including 11 males and 7 females, with CHD but died of mechanical injuries and poisoning as control group I, and 17 cases without CHD who also died of mechanical injuries and poisoning including 10 males and 7 females, as control group II. After HE-stained and immunohistochemistry-stained (SP) for the slices, the expression of AR in coronary arteries were observed and the average optical density (AOD) of positive signal in each case were detected by using Image-Pro Plus 6.0 software. We found strongly positive expression of AR in control group II, weakly positive expression in control group I and a little weaker in the experimental group. The expression of AR in coronary artery was reduced in CHD patients, which suggested that androgen may have favorable effects on the cardiovascular system.
Indexed as
Identifiers
26097556PMC4466943W2434563915What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.