Evidence map›Paper›PMID 26097536›Full record

ArticleInternational journal of clinical and experimental pathology2015

Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.

Yi Jiang, Liyan Liao, Chandrama Shrestha, Daiqiang Li, Meirong Li, Ying Mu, Debra Crumrine, Larry Wang, Zhongjian Xie

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi JiangDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Liyan LiaoDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Chandrama ShresthaDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Daiqiang LiDepartment of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Meirong LiDepartment of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Ying MuDepartment of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Debra CrumrineEndocsrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, CA 94121, USA.
Larry WangDepartment of Pathology, Children's Hospital Los Angeles, University of Southern California Los Angeles, CA 90027, USA.
Zhongjian XieDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China ; Endocsrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, CA 94121, USA.
Central South University · CNChildren's Hospital of Los Angeles · USNorthern California Institute for Research and Education · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium is a strong inducer of keratinocyte differentiation. We have previously demonstrated that extracellular calcium promotes keratinocyte differentiation via E-cadherin-catenin complex-mediated phospholipase C-γ1 (PLC-γ1) activation in the plasma membrane. However, it is unclear whether dietary calcium regulates keratinocyte proliferation, differentiation or carcinogenesis. To address this issue, the rates of oral tumor and levels of proliferation and differentiation in the oral epithelium were assessed in mice on different calcium diets and the carcinogen 4-nitroquinoline-1-oxide. The results showed that mice on the high calcium diet had lower rates of oral tumors, lower levels of proliferation and higher levels of differentiation in the normal oral epithelium than those on the normal calcium diet. Higher levels of E-cadherin, β-catenin, p120-catenin (p120), epidermal growth factor receptor (EGFR), and calcium and lower levels of PLC-γ1 were also noted in the normal oral epithelium in mice on high calcium diet than the control mice. In contrast, mice on low calcium diet had opposite effects. However, dietary calcium had no effect on the proliferation, differentiation or the levels of E-cadherin, β-catenin, p120, PLC-γ1 and EGFR in oral tumors. These data indicate that dietary calcium increases calcium levels in oral epithelium, suppresses oral carcinogenesis, inhibits proliferation and promotes differentiation of normal oral epithelium. Increased E-cadherin, β-catenin, p120 and EGFR and decreased PLC-γ1 may participate in the inhibitory effect of dietary calcium in oral carcinogenesis.

Indexed as

4-Nitroquinoline-1-oxideAnimalsBiomarkersCalcium, DietaryCarcinogenesisCell DifferentiationCell ProliferationDisease Models, AnimalHumansKeratinocytesMiceMice, Inbred C57BLMouth NeoplasmsRandom Allocation4-Nitroquinoline-1-oxideBiomarkersCalcium, DietaryCalciumdifferentiationoral carcinogenesisproliferation

Identifiers

PMID26097536
PMCPMC4466923
OpenAlexW2471006878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.