Evidence map›Paper›PMID 26097499›Full record

ArticleJournal of molecular and genetic medicine : an international journal of biomedical research2015

High-Fat Diet Alters the Orosensory Sensitivity to Fatty Acids in Obesity-Resistant but not Obesity-Prone Rats.

David W Pittman, Dane R Hansen, Timothy A Gilbertson

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular and genetic medicine : an international journal of biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David W PittmanDepartment of Psychology, Wofford College, USA.
Dane R HansenDepartment of Biology, Utah State University, USA.
Timothy A GilbertsonDepartment of Biology, Utah State University, USA.
Wofford College · US

Funding

MECHANISMS OF PERIPHERAL FAT DETECTIONR01DK059611 · NIDDK · UTAH STATE UNIVERSITY · PI GILBERTSON, TIMOTHY A. · 2000 to 2010
$1.8M
FATTY ACID RECEPTORS IN GUSTATIONR01DC013318 · NIDCD · UTAH STATE UNIVERSITY · PI GILBERTSON, TIMOTHY A. · 2014 to 2018
$1.5M
MECHANISMS OF PERIPHERAL FAT DETECTIONR56DK059611 · NIDDK · UTAH STATE UNIVERSITY · PI GILBERTSON, TIMOTHY A. · 2008 to 2008
$277k
NIDCD NIH HHS R01 DC013318NIDDK NIH HHS R01 DK059611NIDDK NIH HHS R56 DK059611
6 · The paper itself

Abstract

Gene-environment interactions play a role in the development of obesity but specific effects of diet on the orosensory detection of fatty acids have yet to be clarified. The objective of this study is to characterize the effect of prolonged (5-week) exposure to a high-fat (60%) diet on the behavioral sensitivity to the fatty acid linoleate following a conditioned taste aversion in obesity-prone and obesity-resistant rats. Exposure to the high-fat diet significantly enhanced the sensitivity of obesity-resistant (S5B/Pl) rats to linoleate while producing no effect on the fatty acid sensitivity for obesity-prone rats. Specifically, high-fat diet fed S5B/Pl rats showed stronger initial avoidance of linoleate and slower extinction rates than their normal diet cohorts. Our study suggests that prolonged dietary fat consumption may alter the behavioral sensitivity to fatty acids particularly in obesity-resistant animals.

Indexed as

Dietary fatFatty acidsObesity phenotypesRat modelsTaste sensitivity

Identifiers

PMID26097499
PMCPMC4470254
OpenAlexW1170918222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.