Evidence map›Paper›PMID 26097455›Full record

ArticleFrontiers in aging neuroscience2015

Outcome measures for hand function naturally reveal three latent domains in older adults: strength, coordinated upper extremity function, and sensorimotor processing.

Emily L Lawrence, Sudarshan Dayanidhi, Isabella Fassola, Philip Requejo, Caroline Leclercq, Carolee J Winstein, Francisco J Valero-Cuevas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Emily L LawrenceBrain-Body Dynamics Laboratory, Department of Biomedical Engineering, University of Southern California Los Angeles, CA, USA.
Sudarshan DayanidhiBrain-Body Dynamics Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles, CA, USA.
Isabella FassolaInstitut de la Main, Clinic Jouvenet Paris, France.
Philip RequejoRancho Los Amigos National Rehabilitation Center Downey, CA, USA.
Caroline LeclercqInstitut de la Main, Clinic Jouvenet Paris, France.
Carolee J WinsteinBrain-Body Dynamics Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles, CA, USA.
Francisco J Valero-CuevasBrain-Body Dynamics Laboratory, Department of Biomedical Engineering, University of Southern California Los Angeles, CA, USA ; Brain-Body Dynamics Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles, CA, USA.
University of Southern California · USInstitut de la Main · FRRancho Los Amigos National Rehabilitation Center · US

Funding

Structure &function of the fingers tendinous apparatusR01AR052345 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALERO-CUEVAS, FRANCISCO J · 2005 to 2017
$3.7M
Control of finger movement and force for precision pinchR01AR050520 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALERO-CUEVAS, FRANCISCO J · 2004 to 2014
$2.9M
NIAMS NIH HHS R01 AR050520NIAMS NIH HHS R01 AR052345
6 · The paper itself

Abstract

Understanding the mapping between individual outcome measures and the latent functional domains of interest is critical to a quantitative evaluation and rehabilitation of hand function. We examined whether and how the associations among six hand-specific outcome measures reveal latent functional domains in elderly individuals. We asked 66 healthy older adult participants (38F, 28M, 66.1 ± 11.6 years, range: 45-88 years) and 33 older adults (65.8 ± 9.7 years, 44-81 years, 51 hands) diagnosed with osteoarthritis (OA) of the carpometacarpal (CMC) joint, to complete six functional assessments: hand strength (Grip, Key and Precision Pinch), Box and Block, Nine Hole Pegboard, and Strength-Dexterity tests. The first three principal components suffice to explain 86% of variance among the six outcome measures in healthy older adults, and 84% of variance in older adults with CMC OA. The composition of these dominant associations revealed three distinct latent functional domains: strength, coordinated upper extremity function, and sensorimotor processing. Furthermore, in participants with thumb CMC OA we found a blurring of the associations between the latent functional domains of strength and coordinated upper extremity function. This motivates future work to understand how the physiological effects of thumb CMC OA lead upper extremity coordination to become strongly associated with strength, while dynamic sensorimotor ability remains an independent functional domain. Thus, when assessing the level of hand function in our growing older adult populations, it is particularly important to acknowledge its multidimensional nature-and explicitly consider how each outcome measure maps to these three latent and fundamental domains of function. Moreover, this ability to distinguish among latent functional domains may facilitate the design of treatment modalities to target the rehabilitation of each of them.

Indexed as

agingdexterityhandsensorimotor processingstrength

Identifiers

PMID26097455
PMCPMC4456581
OpenAlexW1605354677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.