Evidence map›Paper›PMID 26097454›Full record

ArticleFrontiers in aging neuroscience2015

Duration-dependent effects of the BDNF Val66Met polymorphism on anodal tDCS induced motor cortex plasticity in older adults: a group and individual perspective.

Rohan Puri, Mark R Hinder, Hakuei Fujiyama, Rapson Gomez, Richard G Carson, Jeffery J Summers

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In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rohan PuriHuman Motor Control Laboratory, School of Medicine, Faculty of Health, University of Tasmania, Hobart TAS, Australia.
Mark R HinderHuman Motor Control Laboratory, School of Medicine, Faculty of Health, University of Tasmania, Hobart TAS, Australia.
Hakuei FujiyamaHuman Motor Control Laboratory, School of Medicine, Faculty of Health, University of Tasmania, Hobart TAS, Australia ; Movement Control and Neuroplasticity Research Group, Department of Kinesiology KU Leuven, Belgium.
Rapson GomezSchool of Health Sciences, Federation University Australia, Ballarat VIC, Australia.
Richard G CarsonTrinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin Dublin, Ireland ; School of Psychology, Queen's University Belfast Belfast, UK.
Jeffery J SummersHuman Motor Control Laboratory, School of Medicine, Faculty of Health, University of Tasmania, Hobart TAS, Australia ; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University Liverpool, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain derived neurotrophic factor (BDNF) Val66Met polymorphism and stimulation duration are thought to play an important role in modulating motor cortex plasticity induced by non-invasive brain stimulation (NBS). In the present study we sought to determine whether these factors interact or exert independent effects in older adults. Fifty-four healthy older adults (mean age = 66.85 years) underwent two counterbalanced sessions of 1.5 mA anodal transcranial direct current stimulation (atDCS), applied over left M1 for either 10 or 20 min. Single pulse transcranial magnetic stimulation (TMS) was used to assess corticospinal excitability (CSE) before and every 5 min for 30 min following atDCS. On a group level, there was an interaction between stimulation duration and BDNF genotype, with Met carriers (n = 13) showing greater post-intervention potentiation of CSE compared to Val66Val homozygotes homozygotes (n = 37) following 20 min (p = 0.002) but not 10 min (p = 0.219) of stimulation. Moreover, Met carriers, but not Val/Val homozygotes, exhibited larger responses to TMS (p = 0.046) after 20 min atDCS, than following 10 min atDCS. On an individual level, two-step cluster analysis revealed a considerable degree of inter-individual variability, with under half of the total sample (42%) showing the expected potentiation of CSE in response to atDCS across both sessions. Intra-individual variability in response to different durations of atDCS was also apparent, with one-third of the total sample (34%) exhibiting LTP-like effects in one session but LTD-like effects in the other session. Both the inter-individual (p = 0.027) and intra-individual (p = 0.04) variability was associated with BDNF genotype. In older adults, the BDNF Val66Met polymorphism along with stimulation duration appears to play a role in modulating tDCS-induced motor cortex plasticity. The results may have implications for the design of NBS protocols for healthy and diseased aged populations.

Indexed as

BDNFcorticospinal excitabilitymotor cortexolder adultsplasticitytranscranial direct current stimulation (tDCS)transcranial magnetic stimulation (TMS)Val66Met polymorphism

Identifiers

PMID26097454
PMCPMC4456583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.