Evidence map›Paper›PMID 26097406›Full record

ArticleEuropean journal of organic chemistry2015

Generation and Trapping of Ketenes in Flow.

Cyril Henry, David Bolien, Bogdan Ibanescu, Sally Bloodworth, David C Harrowven, Xunli Zhang, Andy Craven, Helen F Sneddon, Richard J Whitby

Abstract read
In one paragraph

Article in European journal of organic chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cyril HenryChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
David BolienChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
Bogdan IbanescuChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
Sally BloodworthChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
David C HarrowvenChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
Xunli ZhangBioengineering Group, Faculty of Engineering and the Environment, University of Southampton Southampton, HANTS, SO17 1BJ, UK.
Andy CravenGlaxoSmithKline R&D Ltd., Medicines Research Centre Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK.
Helen F SneddonGlaxoSmithKline R&D Ltd., Medicines Research Centre Gunnels Wood Road, Stevenage, HERTS, SG1 2NY, UK.
Richard J WhitbyChemistry, University of Southampton Southampton, HANTS, SO17 1BJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketenes were generated by the thermolysis of alkoxyalkynes under flow conditions, and then trapped with amines and alcohols to cleanly give amides and esters. For a 10 min reaction time, temperatures of 180, 160, and 140 °C were required for >95 % conversion of EtO,

Indexed as

AcylationAmidesEstersFlow chemistryKetenesKinetics

Identifiers

PMID26097406
PMCPMC4464552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.