Evidence map›Paper›PMID 26097403›Full record

ArticleJournal of inclusion phenomena and macrocyclic chemistry2012

A thermodynamic study of the cyclodextrin-UC781 inclusion complex using a HPLC method.

Haitao Yang, Michael A Parniak, Sharon L Hillier, Lisa C Rohan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inclusion phenomena and macrocyclic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Haitao YangDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Michael A ParniakDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sharon L HillierMagee-Womens Research Institute, 204 Craft Avenue, B509, Pittsburgh, PA 15213, USA.
Lisa C RohanDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USCraft Engineering Associates (United States) · USMagee-Womens Research Institute · US

Funding

Tissue Explant Model to Evaluate Anti-HIV MicrobicidesU19AI051661 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI HILLIER, SHARON L. · 2002 to 2006
$8.2M
NIAID NIH HHS U19 AI051661
6 · The paper itself

Abstract

UC781, a very potent HIV-1 non-nucleoside reverse transcriptase inhibitor with extreme hydrophobicity and poor water solubility, is under development as a topical vaginal microbicide product to prevent HIV transmission. In this study, the thermodynamic behavior of the interaction between UC781 with three cyclodextrins (CDs): β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and methyl-β-cyclodextrin (MβCD), was investigated using a reversed-phase HPLC method. A mobile phase consisting of acetonitrile: H

Indexed as

EnthalpyHPLCNon-nucleoside reverse transcriptase inhibitor (NNRTI)ThermodynamicsUC781β-cyclodextrin inclusion complex

Identifiers

PMID26097403
PMCPMC4472443
OpenAlexW1994357639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.