ArticleBehavioural brain research2015
Intermittent-access binge consumption of sweet high-fat liquid does not require opioid or dopamine receptors in the nucleus accumbens.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- Stimuli predicting high-calorie reward increase dopamine release and drive approach to food in the absence of homeostatic need.Nutritional neuroscience · 2022Article
- A literature review of dopamine in binge eating.Journal of eating disorders · 2022Review
- Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats.ACS chemical neuroscience · 2019Article
- Article
- Intra-accumbens Raclopride Administration Prevents Behavioral Changes Induced by Intermittent Access to Sucrose Solution.Frontiers in neuroscience · 2018Article
- Reassessing wanting and liking in the study of mesolimbic influence on food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.Behavioural brain research · 2016Article
- Activation of Dopamine Receptors in the Nucleus Accumbens Promotes Sucrose-Reinforced Cued Approach Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Binge eating disorders are characterized by episodes of intense consumption of high-calorie food. In recently developed animal models of binge eating, rats given intermittent access to such food escalate their consumption over time. Consumption of calorie-dense food is associated with neurochemical changes in the nucleus accumbens, including dopamine release and alterations in dopamine and opioid receptor expression. Therefore, we hypothesized that binge-like consumption on intermittent access schedules is dependent on opioid and/or dopamine neurotransmission in the accumbens. To test this hypothesis, we asked whether injection of dopamine and opioid receptor antagonists into the core and shell of the accumbens reduced consumption of a sweet high-fat liquid in rats with and without a history of intermittent binge access to the liquid. Although injection of a μ opioid agonist increased consumption, none of the antagonists (including μ opioid, δ opioid, κ opioid, D1 dopamine and D2 dopamine receptor antagonists, as well as the broad-spectrum opioid receptor antagonist naltrexone) reduced consumption, and this was the case whether or not the animals had a prior history of intermittent access. These results suggest that consumption of sweet, fatty food does not require opioid or dopamine receptor activation in the accumbens even under intermittent access conditions that resemble human binge episodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.