ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed, 221 citations in OpenAlex.
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Extended amygdala orchestrates social motivation in socially isolated mice.bioRxiv : the preprint server for biology · 2026Article
- Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Article
- HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health.Journal of ovarian research · 2026Review
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Article
- The Bed Nucleus of the Stria Terminalis-Deep Mesencephalic Nucleus Circuit Linking Emotion and Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Head Color Morph- and Sex-Specific Differences in Follistatin Gene Expression in the Gouldian Finch Brain.The Journal of comparative neurology · 2025Article
- A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety.The Journal of clinical investigation · 2025Article
- Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal.Cell reports · 2025Article
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (Microtus ochrogaster).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Distinct Impact of Inflammatory Versus Psychophysiological Stress on Brain-Wide Activation of Melanocortin Receptor 4-Expressing Neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Biased Information Routing Through the Basolateral Amygdala, Altered Valence Processing, and Impaired Affective States Associated With Psychiatric Illnesses.Biological psychiatry · 2025Review
- PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Role of the bed nucleus of the stria terminalis in feeding.Frontiers in nutrition · 2025Review
- Neonatal testosterone exposure alleviates female-specific severity of formalin-induced inflammatory pain in mice.Frontiers in neural circuits · 2025Article
- General anesthesia activates a central anxiolytic center in the BNST.Cell reports · 2024Article
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (bioRxiv : the preprint server for biology · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The anterior bed nucleus of the stria terminalis (BNST) has been recognized as a critical structure in regulating trait anxiety, contextual fear memory, and appetitive behavior, and is known to be sensitive to stress manipulations. As one of the most complex structures in the central nervous system, the intrinsic circuitry of the BNST is largely unknown; however, recent technological developments have allowed researchers to begin to untangle the internal connections of the nucleus. This research has revealed the possibility of two opposing circuits, one anxiolytic and one anxiogenic, within the BNST, the relative strength of which determines the behavioral outcome. The balance of these pathways is critical in maintaining a normal physiological and behavioral state; however, stress and drugs of abuse can differentially affect the opposing circuitry within the nucleus to shift the balance to a pathological state. In this review, we will examine how stress interacts with the neuromodulators, corticotropin-releasing factor, norepinephrine, dopamine, and serotonin to affect the circuitry of the BNST as well as how synaptic plasticity in the BNST is modulated by stress, resulting in long-lasting changes in the circuit and behavioral state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.