ArticleSeminars in dialysis
Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.
Article in Seminars in dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Clinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review.CNS drugs · 2026Pooled it
- Ultrasound-Guided Alcohol Neurolysis for Poststroke Upper Limb Spasticity to Facilitate Arteriovenous Fistula Creation in Hemodialysis: A Case Report.Archives of rehabilitation research and clinical translation · 2026Article
- Ten tips for the first hemodialysis sessions.Clinical kidney journal · 2026Review
- Article
- Perioperative Management of the Patient Receiving Maintenance Hemodialysis.Anesthesiology · 2025Article
- Neurological adverse events associated with baclofen: A disproportionality analysis based on FDA Adverse Event Reporting System.SAGE open medicine · 2025Article
- Article
- Article
- Baclofen-induced myoclonus in patients with renal impairment: A case series.SAGE open medical case reports · 2023Article
- Baclofen therapeutics, toxicity, and withdrawal: A narrative review.SAGE open medicine · 2021Review
- Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis.Cureus · 2020Article
- A Case Report of Baclofen Toxicity in a Pediatric Patient With Normal Kidney Function Successfully Treated With Hemodialysis.Canadian journal of kidney health and disease · 2020Article
- Article
- Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.BMC nephrology · 2018Article
- Medical safety in the care of the person with end-stage kidney disease.Seminars in dialysis · 2018Review
- Baclofen-Related Neurotoxicity: Implication in a Fatality Associated With Hepatorenal Syndrome.Clinical medicine insights. Case reports · 2017Article
- Baclofen-induced neurotoxicity in a dialysis patient managed with continuous venovenous hemodialysis: A case report and literature review.Turkish journal of emergency medicineArticle
- Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily dependent on intact renal function, and the contraindication for use in patients with insufficient renal function is not well recognized by healthcare providers. Here, the authors report a series of mild to severe cases of baclofen intoxication in patients with end-stage renal disease. In all cases, baclofen was initiated by either inpatient or outpatient healthcare providers and the patients generally presented with altered mentation, somnolence, and/or respiratory depression. All patients were treated with aggressive hemodialysis and made a full recovery. This paper will briefly review the literature regarding baclofen intoxication, safety of baclofen use in renal disease, and efficacy of extracorporeal therapy in the treatment of baclofen intoxication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.