ArticleHuman brain mapping2015
Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White Matter Abnormalities in Patients With Parkinson's Disease: A Meta-Analysis of Diffusion Tensor Imaging Using Tract-Based Spatial Statistics.Frontiers in aging neuroscience · 2020Pooled it
- Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.NeuroImage. Clinical · 2022Trial
- Prediction of impulse control disorders in Parkinson's disease through a longitudinal machine learning study.NPJ Parkinson's disease · 2026Article
- Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease.Nature communications · 2025Article
- The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics.International journal of molecular sciences · 2023Review
- Cognitive Training in Parkinson's Disease Induces Local, Not Global, Changes in White Matter Microstructure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Assessment of Functional Activities in Individuals with Parkinson's Disease Using a Simple and Reliable Smartphone-Based Procedure.International journal of environmental research and public health · 2020Article
- Exercise and Parkinson's Disease.Advances in experimental medicine and biology · 2020Review
- Processing speed is related to striatal dopamine transporter availability in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Article
- Dopamine affects short-term memory corruption over time in Parkinson's disease.NPJ Parkinson's disease · 2019Article
- Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Dopamine-related dissociation of cortical and subcortical brain activations in cognitively unimpaired Parkinson's disease patients OFF and ON medications.Neuropsychologia · 2018Article
- Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks.Aging medicine (Milton (N.S.W)) · 2018Article
- Can neuroimaging predict dementia in Parkinson's disease?Brain : a journal of neurology · 2018Review
- Transcranial magnetic stimulation does not improve mild cognitive impairment in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- Anti-saccades predict cognitive functions in older adults and patients with Parkinson's disease.PloS one · 2018Article
- Neuroplasticity of cognitive control networks following cognitive training for chronic traumatic brain injury.NeuroImage. Clinical · 2018Article
- Partial lesion of the nigrostriatal dopamine pathway in rats impairs egocentric learning but not spatial learning or behavioral flexibility.Behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveParkinson's disease (PD) often entails impairments of executive functions, such as planning. Although widely held that these impairments arise from dopaminergic denervation of the striatum, not all executive functions are affected early on, and the underlying neural dynamics are not fully understood. In a combined longitudinal and cross-sectional study, we investigated how planning deficits progress over time in the early stages of PD compared to matched healthy controls. We used functional magnetic resonance imaging (fMRI) to identify accompanying neural dynamics.
methodsSeventeen PD patients and 20 healthy controls performed a parametric Tower of London task at two time points separated by ∼3 years (baseline and follow-up). We assessed task performance longitudinally in both groups; at follow-up, a subset of participants (14 patients, 19 controls) performed a parallel version of the task during fMRI. We performed meta-analyses to localize regions-of-interest (ROIs), that is, the bilateral dorsolateral prefrontal cortex (DLPFC), inferior parietal cortex, and caudate nucleus, and performed group-by-task analyses and within-group regression analyses of planning-related neural activation. We studied task-related functional connectivity of seeds in the DLPFC and caudate nucleus.
resultsPD patients, compared with controls, showed impaired task performance at both time-points, while both groups showed similar performance reductions from baseline to follow-up. Compared to controls, patients showed lower planning-related brain activation together with decreased functional connectivity.
conclusionThese findings support the notion that planning is affected early in the PD disease course, and that this impairment in planning is accompanied by decreases in both task-related brain activity and connectivity.
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