ArticleCNS neuroscience & therapeutics2015
Head Transplantation in Mouse Model.
Article in CNS neuroscience & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Ethics of Human Brain Organoid Transplantation in Animals.Neuroethics · 2023Article
- Article
- Ethical, Social & Psychological Challenges of Head Transplantation in Human.Iranian journal of public health · 2018Article
- Is it time to perform the first human head transplant? Comment on the CSA (cephalosomatic anastomosis) paper by Ren, Canavero, and colleagues.Surgical neurology international · 2018Article
- Is it time to perform the first human head transplant? Comment on the CSA (CephaloSomatic Ansatomisis) paper by Ren, Canavero, and colleagues.Surgical neurology international · 2018Article
- A cross-circulated bicephalic model of head transplantation.CNS neuroscience & therapeutics · 2017Article
- Surgical, ethical, and psychosocial considerations in human head transplantation.International journal of surgery (London, England) · 2017Review
- First cephalosomatic anastomosis in a human model.Surgical neurology international · 2017Article
- The history of head transplantation: a review.Acta neurochirurgica · 2016Review
- The Age of Head Transplants.CNS neuroscience & therapeutics · 2016Article
- Human head transplantation. Where do we stand and a call to arms.Surgical neurology international · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgical practices. The goal of this work was to establish head transplant mouse model, then the next step through the feasible biological model to investigate immune rejection and brain function in next step, thereby promoting the goal of translation of AHBR to the clinic in the future. METHODS AND
resultsOur approach involves retaining adequate blood perfusion in the transplanted head throughout the surgical procedure by establishing donor-to-recipient cross-circulation by cannulating and anastomosing the carotid artery on one side of the body and the jugular vein on the other side. Neurological function was preserved by this strategy as indicated by electroencephalogram and intact cranial nerve reflexes.
conclusionsThe results of this study support the feasibility of this method for avoiding brain ischemia during transplantation, thereby allowing for the possibility of long-term studies of head transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.