Evidence map›Paper›PMID 26096535›Full record

ArticleDrug and alcohol dependence2015

Drug use patterns predict risk of non-fatal overdose among street-involved youth in a Canadian setting.

Goldis Mitra, Evan Wood, Paul Nguyen, Thomas Kerr, Kora DeBeck

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Risk Factors for Drug Overdose in Young People: A Systematic Review of the Literature.Journal of child and adolescent psychopharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Goldis MitraBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Evan WoodBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Paul NguyenBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Thomas KerrBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Kora DeBeckBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; School of Public Policy, Simon Fraser University, Burnaby, BC, Canada. Electronic address: uhri-kd@cfenet.ubc.ca.
AIDS Vancouver · CA

Funding

Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDSU01DA038886 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI DEBECK, KORA, HAYASHI, KANNA · 2015 to 2024
$12.1M
Initiation of injection drug use and HIV risks among street-involved youthR01DA028532 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI WOOD, EVAN · 2010 to 2014
$1.9M
Canadian Institutes of Health Research MOP-102742Canadian Institutes of Health Research MOP-286532NIDA NIH HHS R01 DA028532NIDA NIH HHS R01DA028532NIDA NIH HHS U01 DA038886NIDA NIH HHS U01DA038886
6 · The paper itself

Abstract

backgroundNon-fatal drug overdose is a major cause of morbidity among people who use drugs, although few studies have examined this risk among street-involved youth. We sought to determine the risk factors associated with non-fatal overdose among Canadian street-involved youth who reported illicit drug use.

methodsUsing data from a prospective cohort of street-involved youth in Vancouver, Canada, we identified youth without a history of overdose and employed Cox regression analyses to determine factors associated with time to non-fatal overdose between September 2005 and May 2012.

resultsAmong 615 participants, 98 (15.9%) reported a non-fatal overdose event during follow-up, resulting in an incidence density of 7.67 cases per 100 person-years. In multivariate Cox regression analyses, binge drug use (adjusted hazard ratio [AHR]=1.85; 95% confidence interval [CI]=1.20-2.84), non-injection crystal methamphetamine use (AHR=1.70; 95% CI=1.12-2.58), non-injection prescription opiate use (AHR=2.56; 95% CI=1.36-4.82), injection prescription opiate use (AHR=2.49; 95% CI=1.40-4.45) and injection heroin use (AHR=1.85; 95% CI=1.14-3.00) were positively associated with time to non-fatal overdose. Social, behavioural and demographic factors were not significantly associated with time to non-fatal overdose event.

conclusionsRates of non-fatal overdose were high among street-involved youth. Drug use patterns, in particular prescription opiate use, were associated with overdose. These findings underscore the importance of addiction treatment and prevention efforts aimed at reducing the risk of overdose among youth.

Indexed as

AdolescentAdultCanadaDrug OverdoseFemaleHomeless YouthHumansIncidenceMaleProspective StudiesRisk FactorsSubstance Abuse, IntravenousSubstance-Related DisordersSurvivalYoung AdultIllicit drug useInjection drug useNon-fatal drug overdosePrescription drug usePrescription opiate useStreet-involved youth

Identifiers

PMID26096535
PMCPMC4509965
OpenAlexW1550175788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.