ArticleMovement disorders : official journal of the Movement Disorder Society2015
Educational attainment and motor burden in Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies.Molecular psychiatry · 2024Pooled it
- Trial
- Cognitive and motor reserve in Parkinson's disease: Two sides of the same coin?Journal of neuropsychology · 2026Article
- Parkinson's disease and the concept of resilience, cognitive, and motor reserve.Journal of Parkinson's disease · 2026Review
- Influence of the level of education on cognitive function in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Oxidative Stress-Related Serum Extracellular Vesicle miRNAs Indicate Symptom Severity and Cognitive Decline in Parkinson's Disease.Journal of neurochemistry · 2026Article
- Cortical volumetry and longitudinal cognitive changes in Parkinson's disease: insights from the COPPADIS cohort.Brain imaging and behavior · 2025Article
- Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Disparities in Huntington's disease care and research.Current opinion in neurology · 2025Review
- Quantifying motor-cognitive reserve using a novel multi-modal stress test.Brain communications · 2025Article
- Association between family poverty income ratio and Parkinson's disease in adults aged 40 and older: a study from NHANES 2003-2020.Frontiers in neurology · 2025Article
- Cognitive engagement may slow clinical progression and brain atrophy in Huntington's disease.Scientific reports · 2024Article
- Cognitive reserve and executive functions in dual task gait performance in Parkinson's disease.Experimental brain research · 2024Article
- Motor progression trajectories and risk of mild cognitive impairment in Parkinson's disease: A latent class trajectory model from PPMI cohort.CNS neuroscience & therapeutics · 2024Article
- A person-centered approach to characterizing longitudinal ambulatory impairment in Parkinson's disease.Scientific reports · 2024Article
- Review
- Risk factors for falls in Parkinson's disease: a cross-sectional observational and Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Lifestyle Modulators of Neuroplasticity in Parkinson's Disease: Evidence in Human Neuroimaging Studies.CNS & neurological disorders drug targets · 2024Review
- Review
- Neuronally enriched microvesicle RNAs are differentially expressed in the serums of Parkinson's patients.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveGreater educational attainment is a protective factor for neurodegenerative dementias. If education earlier in life leads to greater cerebral reserve, it may play a similar protective role in Parkinson's disease (PD).
methodsWe conducted a cross-sectional clinical imaging study of 142 subjects with PD. All subjects underwent [(11)C]dihydrotetrabenazine PET to confirm nigrostriatal dopaminergic denervation and brain MRI to estimate adjusted cortical gray matter volume (GMV).
resultsAfter adjusting for possible confounders, including cognitive and dopaminergic covariates, as well as nonspecific neurodegeneration covariates (age, disease duration, and total adjusted cortical GMV), lower years of education remained a significant predictor of higher total MDS-UPDRS motor score (t = -3.28; P = 0.001). Education level associated inversely with white matter (WM) hyperintensities in a post-hoc analysis (n = 83).
conclusionsHigher educational attainment is associated with lower severity of motor impairment in PD. This association may reflect an extranigral protective effect upon WM integrity.
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