Evidence map›Paper›PMID 26096276›Full record

ArticleMarine drugs2015

Structural Characterization of New Peptide Variants Produced by Cyanobacteria from the Brazilian Atlantic Coastal Forest Using Liquid Chromatography Coupled to Quadrupole Time-of-Flight Tandem Mass Spectrometry.

Miriam Sanz, Ana Paula Dini Andreote, Marli Fatima Fiore, Felipe Augusto Dörr, Ernani Pinto

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
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  5. Natural Products That Contain Higher Homologated Amino Acids.Chembiochem : a European journal of chemical biology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Anabaenopeptins fromInternational journal of environmental research and public health · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Miriam SanzFaculty of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl-17-05508-900 São Paulo, SP, Brazil. miriam.sanz.roldan@usp.br.
Ana Paula Dini AndreoteCenter for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, 13400-970 Piracicaba, SP, Brazil. apdini@cena.usp.br.
Marli Fatima FioreCenter for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, 13400-970 Piracicaba, SP, Brazil. fiore@cena.usp.br.
Felipe Augusto DörrFaculty of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl-17-05508-900 São Paulo, SP, Brazil. fadorr@usp.br.
Ernani PintoFaculty of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl-17-05508-900 São Paulo, SP, Brazil. ernani@usp.br.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyanobacteria from underexplored and extreme habitats are attracting increasing attention in the search for new bioactive substances. However, cyanobacterial communities from tropical and subtropical regions are still largely unknown, especially with respect to metabolite production. Among the structurally diverse secondary metabolites produced by these organisms, peptides are by far the most frequently described structures. In this work, liquid chromatography/electrospray ionization coupled to high resolution quadrupole time-of-flight tandem mass spectrometry with positive ion detection was applied to study the peptide profile of a group of cyanobacteria isolated from the Southeastern Brazilian coastal forest. A total of 38 peptides belonging to three different families (anabaenopeptins, aeruginosins, and cyanopeptolins) were detected in the extracts. Of the 38 peptides, 37 were detected here for the first time. New structural features were proposed based on mass accuracy data and isotopic patterns derived from full scan and MS/MS spectra. Interestingly, of the 40 surveyed strains only nine were confirmed to be peptide producers; all of these strains belonged to the order Nostocales (three Nostoc sp., two Desmonostoc sp. and four Brasilonema sp.).

Indexed as

BrazilChromatography, LiquidCyanobacteriaForestsPeptidesSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryPeptidesaeruginosinanabaenopeptolinBrasilonemacyanobacteriacyanopeptolinDesmonostocHPLC-ESI-QTOF-MSmass spectrometryNostocpeptidesstructural elucidation

Identifiers

PMID26096276
PMCPMC4483662
OpenAlexW1958059396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.