ArticleAngewandte Chemie (International ed. in English)2015
A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- RF Heating Effects in CEST NMR with HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- A Frequency-Selective pH-Responsive paraCEST Agent.Angewandte Chemie (International ed. in English) · 2020Article
- Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH.Cancer metastasis reviews · 2019Review
- A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes.Bioconjugate chemistry · 2018Article
- Lanthanide-Based TAngewandte Chemie (International ed. in English) · 2017Article
- Amplifying undetectable NMR signals to study host-guest interactions and exchange.Chemical science · 2016Article
- Gear Up for a pH Shift: A Responsive Iron(II) 2-Amino-6-picolyl-Appended Macrocyclic paraCEST Agent That Protonates at a Pendent Group.Inorganic chemistry · 2016Article
- Functional nanoparticles for magnetic resonance imaging.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.