ArticleJournal of ethnopharmacology2015
Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway.
Article in Journal of ethnopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Phytochemistry, Ethnopharmacology, and Pharmacology ofPlants (Basel, Switzerland) · 2025Review
- Ultrasonic-Assisted Extraction ofNutrients · 2022Article
- Structure-immunomodulatory activity relationships of dietary polysaccharides.Current research in food science · 2022Review
- Immune-Enhancing Activity of Aqueous Extracts fromVaccines · 2020Article
- Antimicrobial and Immunomodulatory Effect of Gum Arabic on Human and Bovine Granulocytes AgainstFrontiers in immunology · 2019Article
- Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model.BMC complementary and alternative medicine · 2018Article
- Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice.Transplantation · 2017Article
- Immunomodulatory Activity of Octenyl Succinic Anhydride Modified Porang (Amorphophallus oncophyllus) Glucomannan on Mouse Macrophage-Like J774.1 Cells and Mouse Primary Peritoneal Macrophages.Molecules (Basel, Switzerland) · 2017Article
- Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes.Neurochemistry international · 2016Article
- An Investigation into the Immunomodulatory Activities of Sutherlandia frutescens in Healthy Mice.PloS one · 2016Article
- Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages.International immunopharmacology · 2015Article
- Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.PloS one · 2015Article
- Activation of RAW264.7 cells by PCp-I, a polysaccharide fromInternational journal of immunopathology and pharmacologyArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
ethnopharmacological relevanceSutherlandia frutescens (L.) R. Br. is an indigenous plant of southern Africa that has been traditionally used for various cancers, infections, and inflammatory conditions. AIM OF THE STUDY: Our aim was to investigate the potential immuno-stimulatory activity of a polysaccharide-enriched fraction (SFPS) from a decoction of S. frutescens. MATERIALS AND
methodsRAW 264.7 cells (a murine macrophage cell line) were used to determine the activities of SFPS on macrophage function. The production of reactive oxygen species (ROS), nitric oxide (NO), and inflammatory cytokines were evaluated in the cells treated with or without SFPS. CLI-095, a toll-like receptor (TLR) 4-specific inhibitor, was used to identify whether or not SFPS exerts its effects through TLR4. An antagonist of endotoxin, polymyxin B, was used to evaluate whether endotoxin present in SFPS contributed to its immune-stimulatory activity.
resultsSFPS exhibited potent immune-stimulatory activity by macrophages. The production of ROS, NO, and tumor necrosis factor (TNF-α) were increased upon exposure to SFPS in a dose-dependent manner. All of these activities were completely blocked by co-treatment with CLI-095, but only partially diminished by polymyxin B.
conclusionWe demonstrate for the first time potent immune-stimulatory activity in a decoction prepared from S. frutescens. We believe that this immune stimulatory activity is due, in part, to the action of polysaccharides present in the decoction that acts by way of TLR4 receptors and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. These findings provide a plausible mechanism through which we can understand some of the medicinal properties of S. frutescens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.