ArticleBrain pathology (Zurich, Switzerland)2016
Maturation and Dysgenesis of the Human Olfactory Bulb.
Article in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- The Neurotrophin Receptor TrkC Contributes to the Development of Diverse Olfactory Bulb Neurons.Cellular and molecular neurobiology · 2026Article
- Olfactory testing in infants with perinatal asphyxia: Enhancing encephalopathy risk stratification for future health outcomes.Neuroscience and biobehavioral reviews · 2025Review
- Olfactory Dysfunction and Limbic Hypoactivation in Temporal Lobe Epilepsy.Human brain mapping · 2024Article
- Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation.International journal of molecular sciences · 2024Article
- Proteoform Analysis of the Human Olfactory System: A Window into Neurodegenerative Diseases.Proteomes · 2024Review
- The olfactory striae: A historical perspective on the inconsistent anatomy of the bulbar projections.Journal of anatomy · 2024Review
- Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.Journal of neurology · 2023Article
- Neuromorphological Atlas of Human Prenatal Brain Development: White Paper.Life (Basel, Switzerland) · 2023Article
- The frontal sharp transient in newborns: An endogenous neurobiomarker concomitant to the physiological and critical transitional period around delivery?Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Axonal pathfinding during the development of the nervous system.Annals of the Child Neurology Society · 2023Review
- Sequences of synaptogenesis in the human fetal and neonatal brain by synaptophysin immunocytochemistry.Frontiers in cellular neuroscience · 2023Review
- Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection.Brain sciences · 2022Article
- Olfactory Dysfunction, Headache, and Mental Clouding in Adults with Long-COVID-19: What Is the Link between Cognition and Olfaction? A Cross-Sectional Study.Brain sciences · 2022Article
- Novel insights into the development of the avian nasal cavity.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Olfactory Malformations in Mendelian Disorders of the Epigenetic Machinery.Frontiers in cell and developmental biology · 2020Article
- Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.Frontiers in aging neuroscience · 2020Article
- Assessing Olfaction Using Ultrasonic Vocalization Recordings in Mouse Pups with a Sono-olfactometer.Bio-protocol · 2019Article
- Exploring early human brain development with structural and physiological neuroimaging.NeuroImage · 2019Review
- Congenital Cytomegalovirus Infection Alters Olfaction Before Hearing Deterioration In Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Comparative study of chemical neuroanatomy of the olfactory neuropil in mouse, honey bee, and human.Biological cybernetics · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory bulb with its unique architecture was studied for neuronal maturation in human fetuses. Neuroblasts stream into the olfactory bulb from the rostral telencephalon and secondarily migrate radially. The transitory olfactory ventricular recess regresses postnatally. Olfactory is the only sensory system without thalamic projections but incorporates intrinsic thalamic equivalents. The bulb is a repository of progenitor cells. Maturation of the bulb and tract was studied in 18 normal human fetuses of 16-41 weeks gestation; mid-gestational twins with hydrocephalus; 7 arrhinencephaly/holoprosencephaly; 2 olfactory dysgeneses. Multiple immunoreactivities were performed. Synaptophysin around mitral neurons, in a few synaptic glomeruli and concentric lamination of the outer granular layer, was seen at 16 weeks. Outer granular neurons exhibited NeuN at 16 weeks, only 2/3 were reactive at term. Concentric alternating sheets of granular neurons and their dendrodendritic synapses are seen during maturation. Calretinin reactivity is seen in neurons and neurites, primary olfactory nerve axons, periglomerular cells and neuroepithelial cells surrounding the ventricular recess; reactivity occurs later in synaptic glomeruli than with synaptophysin; not all glomeruli are strongly reactive even at term. Nestin- and vimentin-reactive bipolar progenitor cells were demonstrated at all ages and extend into the olfactory tract. Myelin is demonstrated by Luxol fast blue (LFB) only postnatally. In hydrocephalus, the olfactory recess is dilated. Mitral cell dispersion, disrupted glomeruli, heterotopia and maturational delay are seen in some dysgeneses. Malformations exhibit unique findings. Fusion of hypoplastic bulbs can occur. Abnormal architecture is seen in hemimegalencephaly. More documentation of olfactory dysgenesis is needed in other major brain malformations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.