ReviewPulmonary pharmacology & therapeutics2015
Oxidative stress as activators of sensory nerves for cough.
Review in Pulmonary pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Neuroimmune Mechanisms in Equine Asthma: Primary Inflammatory Triggers, Neuroimmune Modulation and Chronic Airway Remodelling.Animals : an open access journal from MDPI · 2026Review
- Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents.Journal of neurophysiology · 2025Article
- The Potential Role of Oxidative Stress in Modulating Airway Defensive Reflexes.Antioxidants (Basel, Switzerland) · 2025Review
- Association of lower plasma citric acid with prolonged cough: the Nagahama study.Scientific reports · 2023Article
- Cough-provocation tests with hypertonic aerosols.ERJ open research · 2020Review
- TRPV1 (Transient Receptor Potential Vanilloid 1) Cardiac Spinal Afferents Contribute to Hypertension in Spontaneous Hypertensive Rat.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Mechanistic link between diesel exhaust particles and respiratory reflexes.The Journal of allergy and clinical immunology · 2018Article
- Impaired innate immune gene profiling in airway smooth muscle cells from chronic cough patients.Bioscience reports · 2017Article
- The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target?American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Lavender (Avicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Excessive activation of the cough reflex is a major clinical problem in respiratory diseases. The cough reflex is triggered by activation of nociceptive sensory nerve terminals innervating the airways by noxious stimuli. Oxidative stress is a noxious stimuli associated with inhalation of pollutants and inflammatory airway disease. Here, we discuss recent findings that oxidative stress, in particular downstream of mitochondrial dysfunction, evokes increased electrical activity in airway nociceptive sensory nerves. Mechanisms include activation of transient receptor potential (TRP) channels and protein kinase C. Such mechanisms may contribute to excessive cough reflexes in respiratory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.