ArticleMovement disorders : official journal of the Movement Disorder Society2015
Tremor in the elderly: Essential and aging-related tremor.
Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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49 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review.Cerebellum (London, England) · 2022Pooled it
- Longitudinal Trajectories in Essential Tremor: Evidence From A Seven-Year Follow-Up of Motor and Non-Motor Symptoms.European journal of neurology · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Serum glial fibrillary acidic protein is elevated in early-stage late-onset essential tremor and associated with tremor progression.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Risk of Parkinson's disease in older people with tremor: A population-based prospective study.Journal of Parkinson's disease · 2025Article
- Age-related differences in eye movements and the association with Archimedes spiral tracing performance in young and older adults.Experimental brain research · 2025Article
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- Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin MRI Study.CNS neuroscience & therapeutics · 2025Article
- Archimedes Spiral Ratings: Determinants and Population-Based Limits of Normal.Movement disorders clinical practice · 2024Article
- Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.Scientific reports · 2024Article
- Exploring the link between essential tremor and Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling.NeuroImage. Clinical · 2023Article
- Identification and Characterization of Short-Term Motor Patterns in Rest Tremor of Individuals with Parkinson's Disease.Healthcare (Basel, Switzerland) · 2022Article
- The Italian tremor Network (TITAN): rationale, design and preliminary findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Article
- New horizons in late-onset essential tremor: a pre-cognitive biomarker of dementia?Age and ageing · 2022Article
- Essential tremor plus rest tremor: current concepts and controversies.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Essential tremor and cognitive impairment: who, how, and why.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Relationship between physiological tremor and cognitive function in physically active older women.Physical activity and nutrition · 2022Article
- Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.Neuroscience letters · 2022Article
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4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIsolated tremor in the elderly is commonly diagnosed as essential tremor (ET). The prevalence of tremor increases steeply with increasing age, whereas hereditary tremor is becoming less common. Moreover, late-manifesting tremor seems to be associated with dementia and earlier mortality. We hypothesize that different entities underlie tremor in the elderly.
methodsTwo thousand four hundred forty-eight subjects from the Longitudinal Study of Aging Danish Twins older than 70 y answered screening questions for ET in 2001. Two thousand fifty-six (84%) participants drew Archimedes spirals to measure their tremor severity, and classical aging phenotypes were assessed. A subgroup of 276 individuals fulfilling either screening criteria for ET or being controls were personally assessed. Medications and mortality data are available.
resultsThe spiral score increased with age. The spiral score correlated with tremor severity. For the whole cohort, mortality was significantly correlated with the spiral score, and higher spiral scores were associated with lower physical and cognitive functioning. Multivariate analysis identified higher spiral scores as an independent risk factor for mortality. In contrast, the ET patients did not show an increased but rather a lower mortality rate although it was not statistically significant. Consistent with a slower than normal aging, they were also physically and cognitively better functioning than controls.
conclusionsBecause incident tremors beyond 70 y of age show worse aging parameters and mortality than controls and ET, we propose to label it 'aging-related tremor' (ART). This tremor starts later in life and is accompanied by subtle signs of aging both cognitively and physically. More detailed clinical features and pathogenesis warrant further assessment.
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