ArticleAngewandte Chemie (International ed. in English)2015
Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Targeted Near-Infrared Photoacoustic Probes for Dual-Channel Cartilage and Bone Imaging.Angewandte Chemie (International ed. in English) · 2026Article
- Cationic Peptoids for Systemic In Vivo Cartilage-Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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- CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore.Advanced nanobiomed research · 2023Article
- Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer.Annals of translational medicine · 2023Article
- Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores.ACS pharmacology & translational science · 2023Article
- Physicochemical Descriptors in Biodistribution and Clearance of Contrast Agents.Advanced photonics research · 2023Article
- Ovarian cancer-targeted near-infrared fluorophores for fluorescence-guided surgery.Annals of translational medicine · 2023Article
- 3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration.Bioactive materials · 2023Article
- Microwave-Assisted Synthesis of the Red-Shifted Pentamethine Tetrahydroxanthylium Core with Absorbance within the Near Infrared-II Window.ACS pharmacology & translational science · 2022Article
- P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging.Biomaterials research · 2022Article
- Phototheranostics for multifunctional treatment of cancer with fluorescence imaging.Advanced drug delivery reviews · 2022Review
- NIR fluorescence imaging and treatment for cancer immunotherapy.Journal for immunotherapy of cancer · 2022Review
- Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.View (Beijing, China) · 2022Article
- Near-infrared fluorescence guided surgery: State of the evidence from a health technology assessment perspective.Frontiers in surgery · 2022Review
- Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy.Journal of medicinal chemistry · 2021Article
- Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging.Bioengineering & translational medicine · 2021Article
- Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics.Journal of Zhejiang University. Science. B · 2021Review
- Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A novel class of near-infrared fluorescent contrast agents was developed. These agents target cartilage with high specificity and this property is inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injection and a clearance time of approximately 4 h, these agents bind to all three major types of cartilage (hyaline, elastic, and fibrocartilage) and perform equally well across species. Analysis of the chemical structure similarities revealed a potential pharmacophore for cartilage targeting. Our results lay the foundation for future improvements in tissue engineering, joint surgery, and cartilage-specific drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.