ArticleInternational journal of obesity (2005)2015
Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status.Nutrition research (New York, N.Y.) · 2017Pooled it
- Impact of body composition on vitamin D requirements in healthy adults with vitamin D deficiency.Frontiers in endocrinology · 2025Trial
- Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2024Trial
- Trial
- Effects of chronic endurance exercise training on serum 25(OH)D concentrations in elderly Japanese men.Endocrine · 2018Trial
- Endoscopically Created Dual-Path Intestinal Diversion Using an Incision-Less Anastomosis System in Obese Subjects: 3-Year Results of Nutrition Observation.Physiological research · 2025Article
- High-Volume Liposuction in Lipedema Patients: Effects on Serum Vitamin D.Journal of clinical medicine · 2024Article
- Enhanced Metabolic Effects of Fish Oil When Combined with Vitamin D in Diet-Induced Obese Male Mice.Biomolecules · 2024Article
- Article
- Vitamin D level regulates serum lipids discrepantly in adults with and without dyslipidemia.Endocrine connections · 2023Article
- Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate.EFSA journal. European Food Safety Authority · 2023Article
- Vitamin D in atherosclerosis and cardiovascular events.European heart journal · 2023Review
- The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities.Nutrients · 2021Review
- Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice.Nutrients · 2021Review
- Weight Loss After RYGB Is Associated with an Increase in Serum Vitamin D in a Population with Low Prevalence of Hypovitaminosis D at Low Latitude.Obesity surgery · 2020Article
- Inferring the direction of a causal link and estimating its effect via a Bayesian Mendelian randomization approach.Statistical methods in medical research · 2020Article
- Relationships between circulating 25(OH) vitamin D, leptin levels and visceral adipose tissue volume: results from a 1-year lifestyle intervention program in men with visceral obesity.International journal of obesity (2005) · 2020Article
- Association of serum 25-Hydroxy vitamin D with total and regional adiposity and cardiometabolic traits.PloS one · 2020Article
- Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß-adrenergic stimulation.Physiological reports · 2019Article
- Mobilising vitamin D from adipose tissue: The potential impact of exercise.Nutrition bulletin · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesAlthough weight loss has been associated with changes in circulating 25-hydroxyvitamin D (25(OH)D) levels, the quantification of the increase in 25(OH)D levels as a function of adipose tissue volume loss precisely assessed by imaging has not been reported before. The objective of this substudy was to describe the effects of a 1-year lifestyle intervention on plasma 25(OH)D levels. The relationships between changes in 25(OH)D levels and changes in adiposity volume (total and by adipose tissue compartment) were studied. SUBJECTS/
methodsThis intervention study was performed between 2004 and 2006 and participants were recruited from the general community. Sedentary, abdominally obese and dyslipidemic men (n=103) were involved in a 1-year lifestyle modification program. Subjects were individually counseled by a kinesiologist and a nutritionist once every 2 weeks during the first 4 months with subsequent monthly visits in order to elicit a 500-kcal daily energy deficit and to increase physical activity/exercise habits. Body weight, body composition and fat distribution were assessed by dual-energy X-ray absorptiometry and computed tomography, whereas the 25(OH)D levels were measured with an automated assay.
resultsThe 1-year intervention resulted in a 26% increase in circulating 25(OH)D (from 48±2 nmol l(-1) or 19±0.8 ng ml(-1) (±s.e.m.) to 58±2 nmol l(-1) or 23±0.8 ng ml(-1), P<0.0001) along with a 26% decrease in visceral adiposity volume (from 1947±458 to 1459±532 cm3). One-year increases in 25(OH)D levels correlated inversely with changes in all adiposity indices, especially Δvisceral (r=-0.36, P<0.0005) and Δtotal abdominal (r=-0.37, P<0.0005) adipose tissue volumes.
conclusionsThese results indicate that there is a linear increase in circulating 25(OH)D levels as a function of adiposity volume loss, and therefore suggest a role of adiposity reduction in the management of obesity-associated vitamin D insufficiency.
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Registered trials
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