ArticleThe Annals of thoracic surgery2015
Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations.
Article in The Annals of thoracic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Impact of cardiac patch alignment on restoring post-infarct ventricular function.Biomechanics and modeling in mechanobiology · 2024Article
- Multiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.Acta biomaterialia · 2024Article
- Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes.Scientific reports · 2024Article
- Post-infarct evolution of ventricular and myocardial function.Biomechanics and modeling in mechanobiology · 2023Article
- Contractile Adaptation of the Left Ventricle Post-myocardial Infarction: Predictions by Rodent-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.Journal of molecular and cellular cardiology · 2021Article
- Architected fibrous scaffolds for engineering anisotropic tissues.Biofabrication · 2021Article
- Biomechanics of infarcted left ventricle: a review of modelling.Biomedical engineering letters · 2020Review
- Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine.Acta biomaterialia · 2020Article
- In vivo estimation of elastic heterogeneity in an infarcted human heart.Biomechanics and modeling in mechanobiology · 2018Article
- Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2018Article
- Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.Frontiers in physiology · 2018Article
- Computational sensitivity investigation of hydrogel injection characteristics for myocardial support.Journal of biomechanics · 2017Article
- Modeling of Myocardium Compressibility and its Impact in Computational Simulations of the Healthy and Infarcted Heart.Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference) · 2017Article
- Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.Heart failure reviews · 2016Review
- Computational Investigation of Transmural Differences in Left Ventricular Contractility.Journal of biomechanical engineering · 2016Article
- Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?Seminars in cell & developmental biology · 2016Review
- Sensitivity of left ventricular mechanics to myofiber architecture: A finite element study.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2016Article
- Material stiffness parameters as potential predictors of presence of left ventricle myocardial infarction: 3D echo-based computational modeling study.Biomedical engineering online · 2016Article
- Modifying the mechanics of healing infarcts: Is better the enemy of good?Journal of molecular and cellular cardiology · 2016Review
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10 authors.
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Abstract
backgroundInfarct expansion initiates and sustains adverse left ventricular (LV) remodeling after myocardial infarction (MI) and is influenced by temporal changes in infarct material properties. Data from ex vivo biaxial extension testing support this hypothesis; however, infarct material properties have never been measured in vivo. The goal of the current study was to serially quantify the in vivo material properties and fiber orientation of infarcted myocardium over a 12-week period in a porcine model of MI.
methodsA combination of magnetic resonance imaging (MRI), catheterization, finite element modeling, and numeric optimization was used to analyze posterolateral MI. Specifically, properties were determined by minimizing the difference between in vivo strains and volume calculated from MRI and strains and volume predicted by finite element modeling.
resultsIn 1 week after MI, the infarct region was found to be approximately 20 times stiffer than normal diastolic myocardium. Over the course of 12 weeks, the infarct region became progressively less stiff as the LV dilated and ejection fraction decreased. The infarct thinned by nearly half during the remodeling period, and infarct fiber angles became more circumferentially oriented.
conclusionsThe results reported here are consistent with previously described ex vivo biaxial extension studies of infarct material properties and the circumferential change of collagen orientation in posterolateral infarcts. The current study represents a significant advance in that the method used allows for the serial assessment of an individual infarct in vivo over time and avoids the inherent limitations related to the testing of excised tissues.
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