ArticleTropical medicine & international health : TM & IH2015
The diagnostic accuracy of three rapid diagnostic tests for typhoid fever at Chittagong Medical College Hospital, Chittagong, Bangladesh.
Article in Tropical medicine & international health : TM & IH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04673487 (Comparative Study of Commercially Available Typhoid Point of Care Tests to Benchmark Current and Emerging Tools), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Study of Commercially Available Typhoid Point of Care Tests to Benchmark Current and Emerging Tools
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Rapid diagnostic tests for typhoid and paratyphoid (enteric) fever.The Cochrane database of systematic reviews · 2017Pooled it
- Tick-, flea- and mite-borne pathogens and associated diseases of public health importance in Bangladesh: a review.Infectious medicine · 2024Review
- Clinical characteristics of enteric fever and performance of TUBEX TF IgM test in Indonesian hospitals.PLoS neglected tropical diseases · 2024Article
- Comparative Analysis of Commercially Available Typhoid Point-of-Care Tests: Results of a Prospective and Hybrid Retrospective Multicenter Diagnostic Accuracy Study in Kenya and Pakistan.Journal of clinical microbiology · 2022Article
- Comparison of rapid tests (antigen vs. antibody) for the diagnosis of typhoid in the first and second weeks of fever.Journal of family medicine and primary care · 2022Article
- Assessment of Rapid Diagnostic Tests for Typhoid Diagnosis and Assessment of Febrile Illness Outbreaks in Fiji.The American journal of tropical medicine and hygiene · 2021Article
- Performance of Immunodiagnostic Tests for Typhoid Fever: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2021Review
- The Current Status of Enteric Fever Diagnostics and Implications for Disease Control.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Early Economic Evaluation to Identify the Necessary Test Characteristics of a New Typhoid Test to be Cost Effective in Ghana.PharmacoEconomics - open · 2020Article
- Clinical Evaluation of a Multiplex PCR for the Detection ofThe American journal of tropical medicine and hygiene · 2019Article
- Redefining typhoid diagnosis: what would an improved test need to look like?BMJ global health · 2019Article
- Modelling the cost-effectiveness of a rapid diagnostic test (IgMFA) for uncomplicated typhoid fever in Cambodia.PLoS neglected tropical diseases · 2018Article
- An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.The Journal of infection · 2017Article
- Expression of intra- and extracellular granzymes in patients with typhoid fever.PLoS neglected tropical diseases · 2017Article
- Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa.eLife · 2017Article
- A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh.BMC infectious diseases · 2016Observational
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
objectiveTo determine the diagnostic accuracy of three rapid diagnostic tests (RDTs) for typhoid fever in febrile hospitalised patients in Bangladesh.
methodsFebrile adults and children admitted to Chittagong Medical College Hospital, Bangladesh, were investigated with Bact/Alert(®) blood cultures and real-time PCR to detect Salmonella enterica Typhi and Paratyphi A and assays for Rickettsia, leptospirosis and dengue fever. Acute serum samples were examined with the LifeAssay (LA) Test-it™ Typhoid IgM lateral flow assay detecting IgM antibodies against S. Typhi O antigen, CTKBiotech Onsite Typhoid IgG/IgM Combo Rapid-test cassette lateral flow assay detecting IgG and IgM antibodies against S. Typhi O and H antigens and SD Bioline line assay for IgG and IgM antibodies against S. Typhi proteins.
resultsIn 300 malaria smear-negative febrile patients [median (IQR) age of 13.5 (5-31) years], 34 (11.3%) had confirmed typhoid fever: 19 positive by blood culture for S. Typhi (three blood PCR positive) and 15 blood culture negative but PCR positive for S. Typhi in blood. The respective sensitivity and specificity of the three RDTs in patients using a composite reference standard of blood culture and/or PCR-confirmed typhoid fever were 59% and 61% for LifeAssay, 59% and 74% for the CTK IgM and/or IgG, and 24% and 96% for the SD Bioline RDT IgM and/or IgG. The LifeAssay RDT had a sensitivity of 63% and a specificity of 91% when modified with a positive cut-off of ≥2+ and analysed using a Bayesian latent class model.
conclusionsThese typhoid RDTs demonstrated moderate diagnostic accuracies, and better tests are needed.
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