Evidence map›Paper›PMID 26094920›Full record

SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015

Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015.

Kannan Ramar, Leslie C Dort, Sheri G Katz, Christopher J Lettieri, Christopher G Harrod, Sherene M Thomas, Ronald D Chervin

8 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 381 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
381citing papers in PubMed, 15 pooled it
33.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517150 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III

TypeinterventionalSponsorUniversity of Sao PauloRan2016 to 2018Enrolled60ConditionsObstructive Sleep Apnea, ObesityArmsmandibular advancement device
NCT03754270 nacompletednot on this mapstarted 2019, after this paper: background citation

Evaluation of Treatment Effect of Cervical Collar in Moderate Obstructive Sleep Apnea

TypeinterventionalSponsorUppsala UniversityRan2019 to 2023Enrolled100ConditionsObstructive Sleep ApneaArmsAdvice in lifestyle, Cervical collar
NCT04427111 completednot on this map

Therapeutic Efficiency Analyses of Mandibular Advancement Devices on Obstructive Sleep Apnea Using Polysomnography, Smartphone Sleep Applications, and Simple Pulse Oximeter

TypeobservationalSponsorBahadır EZMEKRan2015 to 2017Enrolled18ConditionsObstructive Sleep ApneaArmsNon-titratable-customized mandibular advancement device
NCT04900285 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Pilot Study for Feasibility of Using an Oral Appliance for Decreasing Snoring

TypeinterventionalSponsorNorton HealthcareRan2021 to 2023Enrolled30ConditionsSnoringArmsDelta Dental Oral Device
NCT06594627 narecruitingnot on this mapstarted 2024, after this paper: background citation

Smart Pillows for Enhancing Sleep Quality_Pilot Study

TypeinterventionalSponsorIndiana UniversityRan2024 to 2027Enrolled24ConditionsSnoring, Obstructive Sleep ApneaArmsSmart pillow
NCT06810479 nacompletednot on this mapstarted 2025, after this paper: background citation

A Randomised, Controlled Cross Over Study Comparing Two Mandibular Advancement Devices in the Treatment of Mild-to-moderate Obstructive Sleep Apnea

TypeinterventionalSponsorZiekenhuis Oost-LimburgRan2025 to 2026Enrolled16ConditionsApnea, ObstructiveArmsPolygraphy, Questionaire, Question
NCT07074288 narecruitingnot on this mapstarted 2025, after this paper: background citation

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives (OSANOVA): Comparison of Mandibular Advancement Device and Hypoglossal Nerve Stimulation Outcomes

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2027Enrolled60ConditionsObstructive Sleep ApneaArmsMAD, HGNS
NCT07679282 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparative Effectiveness of Positive Airway Pressure Therapy, Dental Device, and Atomoxetine-Oxybutynin for Sleep Apnea: the ADAPT-OSA Study

TypeinterventionalSponsorSairam ParthasarathyRan2026 to 2032Enrolled2,400ConditionsObstructive Sleep Apnea (OSA)ArmsPositive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin
3 · Its place in the literature

Who cites it

381 citing papers in PubMed, 15 syntheses or guidelines pooled it, 847 citations in OpenAlex.

  1. Pooled it
  2. Oral appliances for obstructive sleep apnoea in adults.The Cochrane database of systematic reviews · 2026
    Pooled it
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  5. Efficacy of advancement treatments of the stomatognathic system on objective sleepiness in OSA: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Pooled it
  6. Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Pooled it
  7. Pooled it
  8. Dentoskeletal changes of long-term oral appliance treatment in patients with obstructive sleep apnea: A systematic review and meta-analysis.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025
    Pooled it
  9. Pooled it
  10. Effects of aerobic exercise and resistance training on obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Pooled it
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  16. Trial
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  19. Atomoxetine plus oxybutynin for symptomatic snoring and airflow limitation in individuals without moderate-to-severe obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  20. Trial

321 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Kannan RamarMayo Clinic, Rochester, MN.
Leslie C DortUniversity of Calgary, Calgary, Alberta, Canada.
Sheri G KatzAtlanta, GA.
Christopher J LettieriWalter Reed National Military Medical Center, Bethesda, MD.
Christopher G HarrodAmerican Academy of Sleep Medicine, Darien, IL.
Sherene M ThomasAmerican Academy of Sleep Medicine, Darien, IL.
Ronald D ChervinUniversity of Michigan, Ann Arbor, MI.
American Academy of Sleep Medicine · USMayo Clinic in Arizona · USUniversity of Calgary · CAUniversity of Michigan · USWalter Reed National Military Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince the previous parameter and review paper publication on oral appliances (OAs) in 2006, the relevant scientific literature has grown considerably, particularly in relation to clinical outcomes. The purpose of this new guideline is to replace the previous and update recommendations for the use of OAs in the treatment of obstructive sleep apnea (OSA) and snoring.

methodsThe American Academy of Sleep Medicine (AASM) and American Academy of Dental Sleep Medicine (AADSM) commissioned a seven-member task force. A systematic review of the literature was performed and a modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process was used to assess the quality of evidence. The task force developed recommendations and assigned strengths based on the quality of the evidence counterbalanced by an assessment of the relative benefit of the treatment versus the potential harms. The AASM and AADSM Board of Directors approved the final guideline recommendations. RECOMMENDATIONS: 1. We recommend that sleep physicians prescribe oral appliances, rather than no therapy, for adult patients who request treatment of primary snoring (without obstructive sleep apnea). (STANDARD) 2. When oral appliance therapy is prescribed by a sleep physician for an adult patient with obstructive sleep apnea, we suggest that a qualified dentist use a custom, titratable appliance over non-custom oral devices. (GUIDELINE) 3. We recommend that sleep physicians consider prescription of oral appliances, rather than no treatment, for adult patients with obstructive sleep apnea who are intolerant of CPAP therapy or prefer alternate therapy. (STANDARD) 4. We suggest that qualified dentists provide oversight—rather than no follow-up—of oral appliance therapy in adult patients with obstructive sleep apnea, to survey for dental-related side effects or occlusal changes and reduce their incidence. (GUIDELINE) 5. We suggest that sleep physicians conduct follow-up sleep testing to improve or confirm treatment efficacy, rather than conduct follow-up without sleep testing, for patients fitted with oral appliances. (GUIDELINE) 6. We suggest that sleep physicians and qualified dentists instruct adult patients treated with oral appliances for obstructive sleep apnea to return for periodic office visits—as opposed to no follow-up—with a qualified dentist and a sleep physician. (GUIDELINE).

conclusionsThe AASM and AADSM expect these guidelines to have a positive impact on professional behavior, patient outcomes, and, possibly, health care costs. This guideline reflects the state of knowledge at the time of publication and will require updates if new evidence warrants significant changes to the current recommendations.

Indexed as

Practice Guidelines as TopicAdultAgedFemaleFollow-Up StudiesHumansMaleMandibular AdvancementMiddle AgedOrthodontic Appliance DesignOrthodontic Appliances, RemovablePolysomnographyPositive-Pressure RespirationSeverity of Illness IndexSleep Apnea, ObstructiveSnoringmandibular advancementobstructive sleep apneaoral appliancepositive airway pressuresnoring

Identifiers

PMID26094920
PMCPMC4481062
OpenAlexW814012870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.