Evidence map›Paper›PMID 26094889›Full record

Trial reportCell metabolism2015

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Sebastian Brandhorst, In Young Choi, Min Wei, Chia Wei Cheng, Sargis Sedrakyan, Gerardo Navarrete, Louis Dubeau, Li Peng Yap, Ryan Park, Manlio Vinciguerra and 16 more

9 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 485 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
485citing papers in PubMed, 5 pooled it
33.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03340935 nacompletednot on this mapstarted 2017, after this paper: background citation

Safety, Feasibility and Metabolic Effects of the Fasting Mimicking Diet (FMD) in Cancer Patients

TypeinterventionalSponsorFilippo de BraudRan2017 to 2020Enrolled101ConditionsMalignant Neoplasm, CancerArmsFasting mimicking diet
NCT03454282 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Impact of Dietary Intervention on Tumor Immunity: the DigesT Trial.

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2018 to 2020Enrolled100ConditionsBreast Cancer, Melanoma, MalignantArmsFMD
NCT03570125 naunknown statusnot on this mapstarted 2018, after this paper: background citation

BRCA Main Home Nutritional Intervention-random Study

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoRan2018 to 2020Enrolled300ConditionsBRCA1 Mutation, BRCA2 MutationArmsProlon
NCT04962464 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

The Impact of Fasting Mimicking Diet Program and Calorie Mimetic Supplements on Epigenetic Aging

TypeinterventionalSponsorTruDiagnosticRan2021 to 2022Enrolled100ConditionsAgingArmsPeak Human Labs calorie mimetic supplement, Fasting Mimicking Diet
NCT05031429 nacompletednot on this mapstarted 2022, after this paper: background citation

Time Limited Eating in New-Onset Type 1 Diabetes: Feasibility, Acceptability, and Effect on β-cell Function

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2022 to 2023Enrolled12ConditionsType 1 DiabetesArmsTime Limited Eating
NCT05196568 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Pilot Study on the Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic

TypeinterventionalSponsorUniversity of SalentoRan2021 to 2025Enrolled100ConditionsPolycystic Ovarian SyndromeArmsFasting mimicking diet
NCT05698654 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluation of Longevity Diet and Fasting Mimicking Diet Programs on Body Composition, Disease Risk Factors, and Aging Markers: a Randomized Clinical Trial

TypeinterventionalSponsorFondazione Valter LongoRan2023 to 2025Enrolled501ConditionsOverweight, Risk Behavior, ObesityArmsFasting-mimicking diet (FMD), Longevity Diet (LD) + Fasting-mimicking Diet (FMD)
NCT07065955 completednot on this mapstarted 2019, after this paper: background citation

Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases

TypeobservationalSponsorFondazione Valter LongoRan2019 to 2024Enrolled365ConditionsOverweight, Obesity, Metabolic Syndrome, Autoimmune DiseasesArmsLongevity diet alone or in combination with fasting mimicking diet
NCT07255300 narecruitingnot on this mapstarted 2025, after this paper: background citation

Follow up Study of the Effects of the Longevity and the Fasting Mimicking Diet on Body Composition, Age-related Risk Factors and Biomarkers of Aging in a Randomized Study 1 and 2

TypeinterventionalSponsorFondazione Valter LongoRan2025 to 2027Enrolled135ConditionsFat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism ChangesArmsfasting mimicking diet
3 · Its place in the literature

Who cites it

485 citing papers in PubMed, 5 syntheses or guidelines pooled it, 854 citations in OpenAlex.

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425 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 3 countries.

Sebastian BrandhorstLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
In Young ChoiLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Min WeiLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Chia Wei ChengLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Sargis SedrakyanGOFARR Laboratory, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, CA 90089, USA.
Gerardo NavarreteLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Louis DubeauDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Li Peng YapMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Ryan ParkMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Manlio VinciguerraInstitute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, London NW3 2PF, UK.
Stefano Di BiaseLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Hamed MirzaeiLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Mario G MirisolaDepartment of Pathobiology and Medical Biotechnology, University of Palermo, 90100 Palermo, Italy.
Patra ChildressGlobal Medicine Program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Lingyun JiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Susan GroshenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Fabio PennaDepartment of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy.
Patrizio OdettiDepartment of Internal Medicine, University of Genova, 16146 Genova, Italy.
Laura PerinGOFARR Laboratory, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, CA 90089, USA.
Peter S ContiMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Yuji IkenoDepartment of Pathology, Barshop Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Brian K KennedyBuck Institute for Research on Aging, Novato, CA 94945, USA.
Pinchas CohenLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Todd E MorganLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Tanya B DorffNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Valter D LongoLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
University of Southern California · USBuck Institute for Research on Aging · USThe Royal Free Hospital · GBThe University of Texas Health Science Center at San Antonio · USUniversity of Genoa · ITUniversity of Palermo · ITUniversity of Turin · IT

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETER J HORNSBY · 1995 to 2026
$30.6M
The Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2011 to 2016
$9.3M
Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage inR01AG020642 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2003 to 2017
$4.8M
Chronological Age-Dependent Genomic Instability in YeastR01AG025135 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2006 to 2010
$1.3M
Optical Resources for Molecular Imaging CenterS10RR017964 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BADING, JAMES R · 2003 to 2003
$250k
NCRR NIH HHS S10 RR017964NCRR NIH HHS S10RR017964-01NIA NIH HHS AG025135NIA NIH HHS AG034906NIA NIH HHS AG20642NIA NIH HHS P01 AG034906NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG020642NIA NIH HHS R01 AG025135
6 · The paper itself

Abstract

Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD cycles promoted hippocampal neurogenesis, lowered IGF-1 levels and PKA activity, elevated NeuroD1, and improved cognitive performance. In a pilot clinical trial, three FMD cycles decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.

Indexed as

CognitionFastingLongevityAbdominal FatAdultAgedAgingAnimalsBody WeightCardiovascular DiseasesDietFemaleHumansMaleMiceMice, Inbred C57BL

Identifiers

PMID26094889
PMCPMC4509734
OpenAlexW2168705381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.