ArticleImmunology2015
Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults.
Article in Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat.Viruses · 2021Review
- Immunity to Influenza Infection in Humans.Cold Spring Harbor perspectives in medicine · 2021Review
- T cell immunity to SARS-CoV-2 following natural infection and vaccination.Biochemical and biophysical research communications · 2021Review
- Ontogeny of different subsets of yellow fever virus-specific circulatory CXCR5Scientific reports · 2020Article
- Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.NPJ vaccines · 2020Article
- Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection.Pathogens (Basel, Switzerland) · 2019Article
- The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells.The Journal of infectious diseases · 2019Article
- Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue.Future virology · 2019Review
- Extending the Breadth of Influenza Vaccines: Status and Prospects for a Universal Vaccine.Drugs · 2018Review
- Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.Current opinion in immunology · 2018Review
- Augmented CD4NPJ vaccines · 2018Article
- T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response.Human vaccines & immunotherapeutics · 2018Review
- Follicular Helper T Cells in Systemic Lupus Erythematosus.Frontiers in immunology · 2018Review
- Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination.Scientific reports · 2017Article
- Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells.Science immunology · 2017Article
- Narcolepsy and influenza vaccination-the inappropriate awakening of immunity.Annals of translational medicine · 2016Article
- Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection.Journal of virology · 2016Article
- The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza.Frontiers in immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CD4 T-cell responses are functionally complex and regulate many aspects of innate and adaptive immunity. Follicular helper (Tfh) cells are CD4 T cells specialized to support B-cell production of isotype-switched, high-affinity antibody. So far, studies of Tfh cells in humans have focused on their differentiation requirements, with little research devoted to their antigen specificity. Here, after separating circulating human memory CD4 T cells based on expression of CXCR5, a signature marker of Tfh, we have quantified and assayed the influenza protein antigen specificity of blood Tfh cells and CD4 T cells lacking this marker. Through the use of peptide pools derived from nucleoprotein (NP) or haemagglutinin (HA) and a panel of human donors, we have discovered that circulating Tfh cells preferentially recognize peptide epitopes from HA while cells lacking CXCR5 are enriched for specificity toward NP. These studies suggest that reactive CD4 T cells specific for distinct viral antigens may have generalized differences in their functional potential due to their previous stimulation history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.