ArticleNeuron2015
Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases.Acta neuropathologica communications · 2026Pooled it
- C3 and CD47 mediate sensory-motor circuit refinement during spinal cord development.The Journal of experimental medicine · 2026Article
- Cellular and molecular mechanisms of muscle spindle development and function.Physiology (Bethesda, Md.) · 2026Review
- Inductive analysis of the spatial distribution characteristics of neurons that innervate skeletal muscle and their correlation with muscle phenotype.Neural regeneration research · 2026Article
- A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases.bioRxiv : the preprint server for biology · 2026Article
- Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms.bioRxiv : the preprint server for biology · 2025Article
- Position-independent functional refinement within the vagus motor topographic map.bioRxiv : the preprint server for biology · 2024Article
- Air-stepping in the neonatal mouse: a powerful tool for analyzing early stages of rhythmic limb movement development.Journal of neurophysiology · 2024Article
- Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice.Frontiers in endocrinology · 2024Article
- The making of a proprioceptor: a tale of two identities.Trends in neurosciences · 2023Review
- Miswired Proprioception in Amyotrophic Lateral Sclerosis in Relation to Pain Sensation (and in Delayed Onset Muscle Soreness)-Is Piezo2 Channelopathy a Principal Transcription Activator in Proprioceptive Terminals Besides Being the Potential Primary Damage?Life (Basel, Switzerland) · 2023Article
- Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.Nature communications · 2022Article
- NaeLife · 2022Article
- Article
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
- Normal Development and Pathology of Motoneurons: Anatomy, Electrophysiological Properties, Firing Patterns and Circuit Connectivity.Advances in neurobiology · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Review
- Non-uniform upregulation of the autogenic stretch reflex among hindlimb extensors following lateral spinal lesion in the cat.Experimental brain research · 2021Article
- HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord.Development (Cambridge, England) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The construction of spinal sensory-motor circuits involves the selection of appropriate synaptic partners and the allocation of precise synaptic input densities. Many aspects of spinal sensory-motor selectivity appear to be preserved when peripheral sensory activation is blocked, which has led to a view that sensory-motor circuits are assembled in an activity-independent manner. Yet it remains unclear whether activity-dependent refinement has a role in the establishment of connections between sensory afferents and those motor pools that have synergistic biomechanical functions. We show here that genetically abolishing central sensory-motor neurotransmission leads to a selective enhancement in the number and density of such "heteronymous" connections, whereas other aspects of sensory-motor connectivity are preserved. Spike-timing-dependent synaptic refinement represents one possible mechanism for the changes in connectivity observed after activity blockade. Our findings therefore reveal that sensory activity does have a limited and selective role in the establishment of patterned monosynaptic sensory-motor connections.
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