ReviewJournal of cancer research and clinical oncology2016
The recent progress of the mechanism and regulation of tumor necrosis in colorectal cancer.
Review in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Machine learning-supported identification of necrosis in colorectal and pancreatic cancer spheroids.PloS one · 2026Article
- Progressive Deactivation of Hydroxylases Controls Hypoxia-Inducible Factor-1α-Coordinated Cellular Adaptation to Graded Hypoxia.Research (Washington, D.C.) · 2025Article
- Prognostic significance of necrosis in ampullary carcinomas.Irish journal of medical science · 2024Article
- Article
- Immunological and prognostic significance of tumour necrosis in colorectal cancer.British journal of cancer · 2023Article
- Necrosis score as a prognostic factor in stage I-III colorectal cancer: a retrospective multicenter study.Discover oncology · 2023Article
- Protective Effect of HER2 Gene Polymorphism rs24537331 in the Outcome of Canine Mammary Tumors.Animals : an open access journal from MDPI · 2023Article
- Chromosome 12 Open Reading Frame 49 Promotes Tumor Growth and Predicts Poor Prognosis in Colorectal Cancer.Digestive diseases and sciences · 2023Article
- Beneficial Proapoptotic Effect of Heterobasidion Annosum Extract in Colorectal Cancer Xenograft Mouse Model.Molecules (Basel, Switzerland) · 2023Article
- Insights on Ferroptosis and Colorectal Cancer: Progress and Updates.Molecules (Basel, Switzerland) · 2022Review
- Neutrophil infiltration combined with necrosis in the primary tumor is a useful prognostic indicator for three-year disease-free survival time in patients with colorectal cancer.Oncology letters · 2022Article
- New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.International journal of molecular sciences · 2021Article
- A novel multimodal nanoplatform for targeting tumor necrosis.RSC advances · 2021Article
- The Duality of Caspases in Cancer, as Told through the Fly.International journal of molecular sciences · 2021Review
- Biodegradable Hypericin-Containing Nanoparticles for Necrosis Targeting and Fluorescence Imaging.Molecular pharmaceutics · 2020Article
- Review
- Specific N-Linked Glycosylation Patterns in Areas of Necrosis in Tumor Tissues.International journal of mass spectrometry · 2019Article
- Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling.Journal of physiology and biochemistry · 2019Article
- The immune response to secondary necrotic cells.Apoptosis : an international journal on programmed cell death · 2017Review
- Interplay between apoptosis and autophagy in colorectal cancer.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In colorectal cancer (CRC), despite the complex inducing and regulating mechanism in necrosis progress, the prognostic value of tumor necrosis has been reported. It is generally recognized that necrosis is associated with many process involving severe hypoxia, inflammatory responses and angiogenesis, all of which contribute to promote tumor growth and poor prognosis. In addition to local hypoxia, regulation by RIP kinase and the conversion from apoptosis to necrosis can result in necrosis also. Recent studies showed necrosis can be a histopathologic characteristic for special molecular phenotype of CRC. A novel and attractive complementary treatment, tumor necrosis therapy, using radiolabelled compounds avid for necrosis has emerged. However, the complicated regulatory mechanisms of tumor necrosis were rarely reported in CRC, and we collected and reviewed these effect and relevance in CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.