Evidence map›Paper›PMID 26093975›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Hope, optimism and survival in a randomised trial of chemotherapy for metastatic colorectal cancer.

Penelope E Schofield, M R Stockler, D Zannino, N C Tebbutt, T J Price, R J Simes, N Wong, N Pavlakis, D Ransom, E Moylan and 6 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Hope and Anxiety: A Meta-analytic Review.Journal of clinical psychology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Hope and its associated factors in cancer patients undergoing drug therapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  6. Anxiety disorders and all-cause mortality: systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2016
    Pooled it
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Dispositional optimism and all-cause mortality after esophageal cancer surgery: a nationwide population-based cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Hope-related goal cognitions and daily experiences of fatigue, pain, and functional concern among lung cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  18. Article
  19. Resilience in Cancer Patients.Frontiers in psychiatry · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Penelope E SchofieldDepartment of Psychology, Swinburne University of Technology, John Road, Hawthorn, Australia. pschofield@swin.edu.au.
M R StocklerNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
D ZanninoLudwig Institute Oncology Unit, Ludwig Institute for Cancer Research, Melbourne, Australia.
N C TebbuttLudwig Institute Oncology Unit, Ludwig Institute for Cancer Research, Melbourne, Australia.
T J PriceDepartment of Oncology, Queen Elizabeth Hospital, Adelaide, Australia.
R J SimesNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
N WongNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
N PavlakisDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, Australia.
D RansomDepartment of Medical Oncology, St John of God Hospital, Subiaco, Australia.
E MoylanDepartment of Medical Oncology, Liverpool Hospital, Sydney, Australia.
C UnderhillBorder Medical Oncology, Wodonga, Australia.
D WyldDepartment of Medical Oncology, Royal Brisbane and Women's Hospital, Herston, Australia.
I BurnsDepartment of Oncology, St Vincent's Hospital, Melbourne, Australia.
R WardPrince of Wales Clinical School and Lowy Cancer Research Centre, Faculty of Medicine, UNSW, Sydney, Australia.
N WilckenDepartment of Medical Oncology, Westmead Hospital, Sydney, Australia.
M JeffordDepartment of Cancer Experiences Research, Peter MacCallum Cancer Centre, East Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePsychological responses to cancer are widely believed to affect survival. We investigated associations between hope, optimism, anxiety, depression, health utility and survival in patients starting first-line chemotherapy for metastatic colorectal cancer.

methodsFour hundred twenty-nine subjects with metastatic colorectal cancer in a randomised controlled trial of chemotherapy completed baseline questionnaires assessing the following: hopefulness, optimism, anxiety and depression and health utility. Hazard ratios (HRs) and P values were calculated with Cox models for overall survival (OS) and progression-free survival (PFS) in univariable and multivariable analyses.

resultsMedian follow-up was 31 months. Univariable analyses showed that OS was associated negatively with depression (HR 2.04, P < 0.001) and positively with health utility (HR 0.56, P < 0.001) and hopefulness (HR 0.75, P = 0.013). In multivariable analysis, OS was also associated negatively with depression (HR 1.72, P < 0.001) and positively with health utility (HR 0.73, P = 0.014), but not with optimism, anxiety or hopefulness. PFS was not associated with hope, optimism, anxiety or depression in any analyses.

conclusionsDepression and health utility, but not optimism, hope or anxiety, were associated with survival after controlling for known prognostic factors in patients with advanced colorectal cancer. Further research is required to understand the nature of the relationship between depression and survival. If a causal mechanism is identified, this may lead to interventional possibilities.

Indexed as

HopeOptimismAgedAntineoplastic Combined Chemotherapy ProtocolsAnxiety DisordersColorectal NeoplasmsDepressive DisorderDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm MetastasisProportional Hazards ModelsSurveys and QuestionnairesColorectal cancerDepressionHealth utilityHopeOptimismSurvival

Identifiers

PMID26093975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.