Evidence map›Paper›PMID 26093843›Full record

ArticleAnalytical and bioanalytical chemistry2015

Combined fiber probe for fluorescence lifetime and Raman spectroscopy.

Sebastian Dochow, Dinglong Ma, Ines Latka, Thomas Bocklitz, Brad Hartl, Julien Bec, Hussain Fatakdawala, Eric Marple, Kirk Urmey, Sebastian Wachsmann-Hogiu and 3 more

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sebastian DochowInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Dinglong MaDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA.
Ines LatkaInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Thomas BocklitzInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Brad HartlDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA.
Julien BecDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA.
Hussain FatakdawalaDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA.
Eric MarpleEmVision LCC, 1471 F Road, Loxahatchee, FL, 33470, USA.
Kirk UrmeyEmVision LCC, 1471 F Road, Loxahatchee, FL, 33470, USA.
Sebastian Wachsmann-HogiuDepartment of Pathology and Laboratory Medicine and Center for Biophotonics, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA, 95817, USA.
Michael SchmittInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Laura MarcuDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA. lmarcu@ucdavis.edu.
Jürgen PoppInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany. juergen.popp@uni-jena.de.

Funding

Time-Resolved Spectroscopy of Unstable Arterial PlaquesR01HL067377 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARCU, LAURA · 2001 to 2015
$5.2M
Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery GuidanceR01CA187427 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, MARCU, LAURA · 2014 to 2025
$4.6M
Fluorescence lifetime technique for detection of radiation necrosis vs gliomR21CA178578 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARCU, LAURA · 2014 to 2015
$360k
NCI NIH HHS R01 CA187427NCI NIH HHS R21 CA178578NHLBI NIH HHS R01 HL067377
6 · The paper itself

Abstract

In this contribution we present a dual modality fiber optic probe combining fluorescence lifetime imaging (FLIm) and Raman spectroscopy for in vivo endoscopic applications. The presented multi-spectroscopy probe enables efficient excitation and collection of fluorescence lifetime signals for FLIm in the UV/visible wavelength region, as well as of Raman spectra in the near-IR for simultaneous Raman/FLIm imaging. The probe was characterized in terms of its lateral resolution and distance dependency of the Raman and FLIm signals. In addition, the feasibility of the probe for in vivo FLIm and Raman spectral characterization of tissue was demonstrated. Graphical Abstract An image comparison between FLIm and Raman spectroscopy acquired with the bimodal probe onseveral tissue samples.

Indexed as

AnimalsBrain ChemistryEndoscopyEquipment DesignFiber Optic TechnologyHumansOptical ImagingRats, Inbred F344Spectrum Analysis, RamanBimodalFiber probesFluorescence lifetimeImagingRaman spectroscopy

Identifiers

PMID26093843
PMCPMC4995092

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.