Evidence map›Paper›PMID 26093656›Full record

Trial reportPsychopharmacology2015

Assessing the translational feasibility of pharmacological drug memory reconsolidation blockade with memantine in quitting smokers.

Ravi K Das, Chandni Hindocha, Tom P Freeman, Antonio I Lazzarino, H Valerie Curran, Sunjeev K Kamboj

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Genes · 2022
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  16. Addictive behaviour in experimental animals: prospects for translation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ravi K DasClinical Psychopharmacology Unit, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK, ravi.das@ucl.ac.uk.
Chandni Hindocha
Tom P Freeman
Antonio I Lazzarino
H Valerie Curran
Sunjeev K Kamboj

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePreclinical reconsolidation research offers the first realistic opportunity to pharmacologically weaken the maladaptive memory structures that support relapse in drug addicts. N-methyl D-aspartate receptor (NMDAR) antagonism is a highly effective means of blocking drug memory reconsolidation. However, no research using this approach exists in human addicts.

objectivesThe objective of this study was to assess the potential and clinical outcomes of blocking the reconsolidation of cue-smoking memories with memantine in quitting smokers.

methodsFifty-nine dependent and motivated to quit smokers were randomised to one of three groups receiving the following: (1) memantine with or (2) without reactivation of associative cue-smoking memories or (3) reactivation with placebo on their target quit day in a double-blind manner. Participants aimed to abstain from smoking for as long as possible. Levels of smoking and FTND score were assessed prior to intervention and up to a year later. Primary outcome was latency to relapse. Subjective craving measures and attentional bias to smoking cues were assessed in-lab.

resultsAll study groups successfully reduced their smoking up to 3 months. Memantine in combination with smoking memory reactivation did not affect any measure of smoking outcome, reactivity or attention capture to smoking cues.

conclusionsBrief exposure to smoking cues with memantine did not appear to weaken these memory traces. These findings could be due to insufficient reconsolidation blockade by memantine or failure of exposure to smoking stimuli to destabilise smoking memories. Research assessing the treatment potential of reconsolidation blockade in human addicts should focus on identification of tolerable drugs that reliably block reward memory reconsolidation and retrieval procedures that reliably destabilise strongly trained memories.

Indexed as

CuesAdultAttentionCravingDouble-Blind MethodExcitatory Amino Acid AntagonistsFeasibility StudiesFemaleHumansMaleMemantineMemoryMemory ConsolidationMiddle AgedReceptors, N-Methyl-D-AspartateRewardExcitatory Amino Acid AntagonistsMemantineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID26093656
PMCPMC4537501

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.