ArticlePsychopharmacology2015
The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Factors associated with fluoxetine adherence among outpatients with common mental disorders in Western Kenya.BMJ global health · 2025Trial
- Rapid Development and Testing of Behavioral Text Message Reminders for Antidepressant Adherence via Online Panels: Survey Study.Journal of medical Internet research · 2026Article
- Out-of-Pocket Costs and Antidepressant Adherence in Head and Neck Cancer Survivors.Psycho-oncology · 2026Article
- Divergent prefrontal activation between genders in depression during verbal fluency task: evidence from a large-scale fNIRS study.Annals of general psychiatry · 2026Article
- A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.Dialogues in clinical neuroscience · 2025Article
- Treatment persistence and modification patterns of SSRIs in children and adolescents with depression: a nationwide population-based study in South Korea.BMC psychiatry · 2025Article
- Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension.Journal of the American Heart Association · 2024Article
- Effectiveness of health checkup with depression screening on depression treatment and outcomes in middle-aged and older adults: a target trial emulation study.The Lancet regional health. Western Pacific · 2024Article
- Factors Associated With Non-adherence to Anti-depressant Medication in Adults: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study.Pharmaceutics · 2022Article
- Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review.International journal of environmental research and public health · 2022Review
- Drug exposure misclassification in pharmacoepidemiology: Sources and relative impact.Pharmacoepidemiology and drug safety · 2021Article
- Factors Associated with Antidepressant Medication Non-adherenceTurkish journal of pharmaceutical sciences · 2021Article
- The impact of internet use frequency on non-suicidal self injurious behavior and suicidal ideation among Chinese adolescents: an empirical study based on gender perspective.BMC public health · 2020Article
- Differential Medication Attitudes to Antihypertensive and Mood Stabilizing Agents in response to an Automated Text-Messaging Adherence Enhancement Intervention.Journal of behavioral and cognitive therapy · 2020Article
- Sex differences in antidepressant efficacy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex Differences In Psychoeducation For Patients With Depression: A Comparison Of Frequency And Efficacy Of Psychoeducation.Neuropsychiatric disease and treatment · 2019Article
- Depression treatment and healthcare expenditures among elderly Medicare beneficiaries with newly diagnosed depression and incident breast, colorectal, or prostate cancer.Psycho-oncology · 2017Article
- Antidepressant use in suicides: a case-control study from the Friuli Venezia Giulia Region, Italy, 2005-2014.European journal of clinical pharmacology · 2017Article
- Transcranial Direct Current Stimulation: Considerations for Research in Adolescent Depression.Frontiers in psychiatry · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionImpaired adherence is common among patients using antidepressant drugs (ADs). However, few studies investigated the role of age and gender in adherence to AD and finding conflict.
objectiveThis study aimed to determine how gender and age impact adherence to AD in a large-scale cohort.
methodsWe conducted a historical cohort study (N = 310,994 individuals) that claimed AD prescriptions during a 4-year period. Adherence was defined as the ratio between the duration of claimed AD prescriptions and the duration of continuously prescribed AD.
resultsSubstantial differences in the mean adherence to AD were noted throughout the lifespan, ranging from 0.38 (first decade) to 0.63 (tenth decade). Average adherence was significantly higher for males aged 20-40 years than for females of that age, but this relationship reversed later in life (50-70 years). A regression analysis model of adherence as the dependent variable showed a significant interaction between age and gender variables (beta = 0.001, p < 0.0001).
conclusionsThis study demonstrates the effect of age and gender, and their interaction, on adherence to AD across the entire life span. The marked age- and modest, yet significant, gender-related effects should be taken into consideration when targeting impaired adherence to these commonly prescribed medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.