ArticleHormones and behavior2015
Activation of G protein-coupled estrogen receptor 1 (GPER-1) decreases fluid intake in female rats.
Article in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Sex- and site-specific effects of GPER-1 activation on saccharin vs cocaine preference in male and female rats.Hormones and behavior · 2025Article
- Fluid transitions.Neuropharmacology · 2024Review
- The estrogenic reduction in water intake stimulated by dehydration involves estrogen receptor alpha and a potential role for GLP-1.Physiology & behavior · 2024Article
- Sex Differences in Salt Appetite: Perspectives from Animal Models and Human Studies.Nutrients · 2023Review
- G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner.Frontiers in physiology · 2023Article
- Fluid intake, what's dopamine got to do with it?Physiology & behavior · 2021Article
- Bidirectional effects of estradiol on the control of water intake in female rats.Hormones and behavior · 2021Article
- The anti-dipsogenic and anti-natriorexigenic effects of estradiol, but not the anti-pressor effect, are lost in aged female rats.Physiological reports · 2021Article
- Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia.Archives of rheumatology · 2019Article
- 2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.Journal of cardiovascular pharmacology · 2019Article
- Anorexigenic effects of estradiol in the medial preoptic area occur through membrane-associated estrogen receptors and metabotropic glutamate receptors.Hormones and behavior · 2019Article
- Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats.Hormones and behavior · 2018Article
- Sex differences in the drinking response to angiotensin II (AngII): Effect of body weight.Hormones and behavior · 2017Article
- Divergent effects of ERα and ERβ on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
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2 authors at 1 institution in 1 country.
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Abstract
Estradiol (E2) decreases fluid intake in the female rat and recent studies from our lab demonstrate that the effect is at least in part mediated by membrane-associated estrogen receptors. Because multiple estrogen receptor subtypes can localize to the cell membrane, it is unclear which receptor(s) is generating the anti-dipsogenic effect of E2. The G protein-coupled estrogen receptor 1 (GPER-1) is a particularly interesting possibility because it has been shown to regulate blood pressure; many drinking-regulatory systems play overlapping roles in the control of blood pressure. Accordingly, we tested the hypothesis that activation of GPER-1 is sufficient to decrease fluid intake in female rats. In support of this hypothesis we found that treatment with the selective GPER-1 agonist G1 reduced AngII-stimulated fluid intake in OVX rats. Given the close association between food and fluid intakes in rats, and previous reports suggesting GPER-1 plays a role in energy homeostasis, we tested the hypothesis that the effect of GPER-1 on fluid intake was caused by a more direct effect on food intake. We found, however, that G1-treatment did not influence short-term or overnight food intake in OVX rats. Together these results reveal a novel effect of GPER-1 in the control of drinking behavior and provide an example of the divergence in the controls of fluid and food intakes in female rats.
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