ReviewJournal of neuroscience methods2016
Blood-brain barrier, bulk flow, and interstitial clearance in epilepsy.
Review in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Reassessment of the DTI-ALPS index in focal epilepsy.European radiology experimental · 2026Article
- Glymphatic dysfunction couples with cortical excitation-inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis.Epilepsia · 2026Article
- Alterations in glymphatic system and brain morphology in patients with temporal lobe epilepsy.BMC medical imaging · 2026Article
- Comparative Assessment of Quality of Life and Serum S100B in Epilepsy Treated with Newer and Conventional Drugs: A Pharmacoeconomic Perspective.Journal of epilepsy research · 2025Article
- Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis.Epilepsia · 2025Observational
- Diffusion MRI-based analysis of functional alterations of the glymphatic system in children with non-lesional epilepsy.Neuroimage. Reports · 2025Article
- A Versatile Microfluidic Device System that Lacks a Synthetic Extracellular Matrix Recapitulates the Blood-Brain Barrier and Dynamic Tumor Cell Interaction.Bioengineering (Basel, Switzerland) · 2024Article
- Interplay between immune cells and metabolites in epilepsy: insights from a Mendelian randomization analysis.Frontiers in aging neuroscience · 2024Article
- Successful treatment of epileptic encephalopathy with spike wave activation in sleep with anakinra.Epilepsy & behavior reports · 2024Article
- Recovery of glymphatic system function in patients with temporal lobe epilepsy after surgery.European radiology · 2023Article
- The role of the blood-brain barrier during neurological disease and infection.Biochemical Society transactions · 2023Review
- Respiratory brain impulse propagation in focal epilepsy.Scientific reports · 2023Article
- Glymphatic system impairment in patients with status epilepticus.Neuroradiology · 2022Article
- Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury.Brain, behavior, & immunity - health · 2022Article
- Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis.Epilepsia open · 2022Article
- Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery.Current drug metabolism · 2022Review
- Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy-6-month MRI follow-up after experimental traumatic brain injury.Brain structure & function · 2022Article
- Alzheimer's disease and epilepsy: An increasingly recognized comorbidity.Frontiers in aging neuroscience · 2022Review
- Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives.Frontiers in immunology · 2022Review
- Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.JCI insight · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Understanding the pathophysiology of epilepsy implies elucidating the neurovascular modifications occurring before or at time of seizures. Cerebrovascular dysfunction provokes or sustains seizures and loss of selective blood-brain barrier (BBB) permeability is a modulator of seizure threshold. However, cerebrovascular pathology in epilepsy extends beyond BBB "leakage" to encompass vascular and parenchymal events. Whenever abnormal accumulation of protein is observed surrounding brain blood vessels, BBB disruption (BBBD) was invoked. Recent clinical and laboratory findings challenged an exclusive role of BBBD in perivascular accumulation of serum-derived products. The circulation of interstitial fluid (ISF) and its bulk flow have emerged as candidate mechanisms which play a role in clearance of CNS waste. Although controversy exists, changes of ISF flow may contribute to CNS disorders through a mechanism encompassing incomplete parenchymal clearance and accompanying accumulation of toxic byproducts. We summarize the evidence in favor and against ISF bulk flow and propose a scenario where abnormal ISF in the epileptic brain allows accumulation of brain protein, sustaining pathophysiology and altering the pharmacology of antiepileptic drugs. We also describe the methods routinely used to dissect out the contribution of BBB-dependent, vascular or paracellular mechanisms to altered neuronal excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.