ArticleJournal of experimental botany2015
A salt-regulated peptide derived from the CAP superfamily protein negatively regulates salt-stress tolerance in Arabidopsis.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 116 citations in OpenAlex.
- TIME FOR COFFEE coordinates phase separation and chromatin regulation for salt tolerance.Science advances · 2026Article
- Advances in the roles of SCOOP peptides and the receptor-like kinase MIK2 in plant stress responses.Plant cell reports · 2026Review
- Genome-Wide Characterization of CAPE-ProducingPlants (Basel, Switzerland) · 2026Article
- Small Signaling Peptides inPlant direct · 2026Article
- Expression of Small Secreted Peptide Genes in Abiotic Stress in Plants Interacting with Plant Growth-Promoting Bacteria.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026Article
- Plant Peptides on the Rise: From Historical Insight to Future Applications.Plant biotechnology journal · 2026Review
- PROSiCAPE14 regulates salt tolerance through ROS and ion homeostasis in foxtail millet.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Plant cell wall remodeling and peptide signaling under abiotic and biotic stress.Plant communications · 2026Review
- Plant non-canonical peptides: From identification to mechanisms.Plant communications · 2026Review
- The impact of CsPSKs on plant immunity: insights from a genome-wide study of small peptides in Citrus sinensis.Functional & integrative genomics · 2026Article
- Small peptides play a key role as messengers in plant growth, development and abiotic stress resistance.Frontiers in plant science · 2026Review
- The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.Plant communications · 2025Review
- Peptide Hormone-Mediated Regulation of Plant Development and Environmental Adaptability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Salt Stress Mitigation and Field-Relevant Biostimulant Activity of Prosystemin Protein Fragments: Novel Tools for Cutting-Edge Solutions in Agriculture.Plants (Basel, Switzerland) · 2025Article
- The Proteomic and Peptidomic Response of Wheat (Plants (Basel, Switzerland) · 2025Article
- Contrasting roles of reactive oxygen species in pyrophosphate-induced growth inhibition under normal and salt stress conditions.Plant molecular biology · 2025Article
- Research progress of peptides discovery and function in resistance to abiotic stress in plant.Stress biology · 2025Review
- Identification and analysis of VOCs released by Rhodococcus ruber GXMZU2400 to promote plant growth and inhibit pathogen growth.BMC plant biology · 2025Article
- Decoding small peptides: Regulators of plant growth and stress resilience.Journal of integrative plant biology · 2025Review
- Peptide hormones in plants.Molecular horticulture · 2025Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High salinity has negative impacts on plant growth through altered water uptake and ion-specific toxicities. Plants have therefore evolved an intricate regulatory network in which plant hormones play significant roles in modulating physiological responses to salinity. However, current understanding of the plant peptides involved in this regulatory network remains limited. Here, we identified a salt-regulated peptide in Arabidopsis. The peptide was 11 aa and was derived from the C terminus of a cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily. This peptide was found by searching homologues in Arabidopsis using the precursor of a tomato CAP-derived peptide (CAPE) that was initially identified as an immune signal. In searching for a CAPE involved in salt responses, we screened CAPE precursor genes that showed salt-responsive expression and found that the PROAtCAPE1 (AT4G33730) gene was regulated by salinity. We confirmed the endogenous Arabidopsis CAP-derived peptide 1 (AtCAPE1) by mass spectrometry and found that a key amino acid residue in PROAtCAPE1 is critical for AtCAPE1 production. Moreover, although PROAtCAPE1 was expressed mainly in the roots, AtCAPE1 was discovered to be upregulated systemically upon salt treatment. The salt-induced AtCAPE1 negatively regulated salt tolerance by suppressing several salt-tolerance genes functioning in the production of osmolytes, detoxification, stomatal closure control, and cell membrane protection. This discovery demonstrates that AtCAPE1, a homologue of tomato immune regulator CAPE1, plays an important role in the regulation of salt stress responses. Our discovery thus suggests that the peptide may function in a trade-off between pathogen defence and salt tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.