ArticleMolecular biology and evolution2015
Aberrant Time to Most Recent Common Ancestor as a Signature of Natural Selection.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Population Genomic Scans for Natural Selection and Demography.Annual review of genetics · 2024Review
- Forty Years of Inferential Methods in the Journals of the Society for Molecular Biology and Evolution.Molecular biology and evolution · 2024Article
- Inference of Coalescence Times and Variant Ages Using Convolutional Neural Networks.Molecular biology and evolution · 2023Article
- Inferring Balancing Selection From Genome-Scale Data.Genome biology and evolution · 2023Review
- A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection.PLoS biology · 2022Article
- Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection.Molecular biology and evolution · 2020Article
- Detection of Shared Balancing Selection in the Absence of Trans-Species Polymorphism.Molecular biology and evolution · 2019Article
- High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.Nature genetics · 2018Article
- Detecting Recent Positive Selection with a Single Locus Test Bipartitioning the Coalescent Tree.Genetics · 2018Article
- Genome-wide signatures of complex introgression and adaptive evolution in the big cats.Science advances · 2017Article
- The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence.BMC evolutionary biology · 2016Article
- Integrating the signatures of demic expansion and archaic introgression in studies of human population genomics.Current opinion in genetics & development · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Natural selection inference methods often target one mode of selection of a particular age and strength. However, detecting multiple modes simultaneously, or with atypical representations, would be advantageous for understanding a population's evolutionary history. We have developed an anomaly detection algorithm using distributions of pairwise time to most recent common ancestor (TMRCA) to simultaneously detect multiple modes of natural selection in whole-genome sequences. As natural selection distorts local genealogies in distinct ways, the method uses pairwise TMRCA distributions, which approximate genealogies at a nonrecombining locus, to detect distortions without targeting a specific mode of selection. We evaluate the performance of our method, TSel, for both positive and balancing selection over different time-scales and selection strengths and compare TSel's performance with that of other methods. We then apply TSel to the Complete Genomics diversity panel, a set of human whole-genome sequences, and recover loci previously inferred to be under positive or balancing selection.
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