ArticleNeurology2015
Status epilepticus of inflammatory etiology: a cohort study.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 91 citations in OpenAlex.
- Effect of Immunotherapy on Seizure Outcome in Patients with Autoimmune Encephalitis: A Prospective Observational Registry Study.PloS one · 2016Trial
- Rare Variants of Immune-Related Genes Increase Susceptibility to Autoimmune Encephalitis: An Association Study.Neurology international · 2025Article
- Status epilepticus in the ICU.Intensive care medicine · 2024Review
- The three pillars in treating antibody-mediated encephalitis.Wiener klinische Wochenschrift · 2024Review
- Validating Prediction Tools for Autoimmune Encephalitis in Adult Taiwanese Patients: A Retrospective Study.Biomedicines · 2023Article
- Febrile infection-related Epilepsy Syndrome (FIRES): a severe encephalopathy with status epilepticus. Literature review and presentation of two new cases.Italian journal of pediatrics · 2022Review
- Simple and effective serum biomarkers potential for predicting status epilepticus in anti-N-methyl-D-aspartate receptor encephalitis.BMC neurology · 2022Article
- [S2k guidelines: status epilepticus in adulthood : Guidelines of the German Society for Neurology].Der Nervenarzt · 2021Review
- Prevalence of Neural Autoantibodies in Epilepsy of Unknown Etiology: Systematic Review and Meta-Analysis.Brain sciences · 2021Review
- An Insight into the Current Understanding of Status Epilepticus: From Concept to Management.Neurology research international · 2021Review
- Diagnosis and Treatment of Status Epilepticus.Journal of epilepsy research · 2020Review
- Predicting the Functional Outcome of Adult Patients with Status Epilepticus.Journal of clinical medicine · 2019Article
- Antiseizure medications in critical care: an update.Current opinion in critical care · 2019Review
- Intravenous Corticosteroids as an Adjunctive Treatment for Refractory and Super-Refractory Status Epilepticus: An Observational Cohort Study.CNS drugs · 2019Observational
- The Different Clinical Features Between Autoimmune and Infectious Status Epilepticus.Frontiers in neurology · 2019Article
- Treatment of Refractory and Super-refractory Status Epilepticus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Multimodal Predictions of Super-Refractory Status Epilepticus and Outcome in Status Epilepticus Due to Acute Encephalitis.Frontiers in neurology · 2018Article
- Management of Autoimmune Status Epilepticus.Frontiers in neurology · 2018Review
- An unusual case of refractory status epilepticus in a young lady: anti-NMDA receptor encephalitis.Clinical medicine (London, England) · 2017Article
- Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis.Current opinion in neurology · 2017Review
Corrections and comments
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- Commented on byAuthor Response.2016
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInflammation-related epilepsy is increasingly recognized; however, studies on status epilepticus (SE) are very infrequent. We therefore aimed to determine the frequency of inflammatory etiologies in adult SE, and to assess related demographic features and outcomes.
methodsThis was a retrospective analysis of a prospective registry of adult patients with SE treated in our center, from January 2008 to June 2014, excluding postanoxic causes. We classified SE episodes into 3 etiologic categories: infectious, autoimmune, and noninflammatory. Demographic and clinical variables were analyzed regarding their relationship to etiologies and functional outcome.
resultsAmong the 570 SE consecutive episodes, 33 (6%) were inflammatory (2.5% autoimmune; 3.3% infectious), without any change in frequency over the study period. Inflammatory SE episodes involved younger patients (mean age 53 vs 61 years, p = 0.015) and were more often refractory to initial antiepileptic treatment (58% vs 38%, odds ratio = 2.19, 95% confidence interval = 1.07-4.47, p = 0.041), despite similar clinical outcome. Subgroup analysis showed that, compared with infectious SE episodes, autoimmune SE involved younger adults (mean age 44 vs 60 years, p = 0.017) and was associated with lower morbidity (return to baseline conditions in 71% vs 32%, odds ratio = 5.41, 95% confidence interval = 1.19-24.52, p = 0.043) without any difference in mortality.
conclusionsDespite increasing awareness, inflammatory SE etiologies were relatively rare; their occurrence in younger individuals and higher refractoriness to treatment did not have any effect on outcome. Autoimmune SE episodes also occurred in younger patients, but tended to have better outcomes in survivors than infectious SE.
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