Evidence map›Paper›PMID 26092649›Full record

Trial reportBone2015

Effectiveness of resistance training or jumping-exercise to increase bone mineral density in men with low bone mass: A 12-month randomized, clinical trial.

Pamela S Hinton, Peggy Nigh, John Thyfault

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04281264 (Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly), which is not on this map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04281264 nacompletednot on this mapstarted 2019, after this paper: background citation

Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly

TypeinterventionalSponsorUniversity of ExtremaduraRan2019 to 2021Enrolled120ConditionsAging WellArmsPassive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands, Normoxia Vibration, Hypoxia Vibration
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  9. Facilitators and barriers to exercise adherence in patients with osteopenia and osteoporosis: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Pooled it
  10. Trial
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  17. Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  18. Article
  19. Exercise and Musculoskeletal Health in Men With Low Bone Mineral Density: A Systematic Review.Archives of rehabilitation research and clinical translation · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pamela S HintonDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia MO 65211, USA. Electronic address: hintonp@missouri.edu.
Peggy NighDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia MO 65211, USA.
John ThyfaultDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia MO 65211, USA; Internal Medicine - Division of GI and Hepatology, University of Missouri, Columbia MO 65211, USA.
University of Missouri · US

Funding

Aerobic fitness, mitochondrial dysfunction, and fatty liver diseaseR01DK088940 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI THYFAULT, JOHN P · 2011 to 2015
$1.5M
Efficacy of Plyometrics to Increase Bone Mass in MenR03AR055738 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HINTON, PAMELA S · 2009 to 2011
$211k
NIAMS NIH HHS R03 AR055738NIAMS NIH HHS R03AR055738NIDDK NIH HHS R01 DK088940NIDDK NIH HHS R01DK088940
6 · The paper itself

Abstract

purposeTo examine the effects of 12 mo of resistance training (RT, 2×/wk, N=19) or jump training (JUMP, 3×/wk, N=19) on bone mineral density (BMD) and bone turnover markers (BTM) in physically active (≥ 4h/wk) men (mean age: 44 ± 2 y; median: 44 y) with osteopenia of the hip or spine.

methodsParticipants rated pain and fatigue following each RT or JUMP session. All participants received supplemental calcium (1200 mg/d) and vitamin D (10 μg/d). BMD was measured at 0, 6, and 12 mo using DXA scans of the whole body (WB), total hip (TH) and lumbar spine (LS). BTM and 25 OHD were measured by ELISA. The effects of RT or JUMP on BMD and BTM were evaluated using 3x2 repeated measures ANOVA (time, group). This study was conducted in accordance with the Declaration of Helsinki and was approved by the University of Missouri IRB.

resultsAt baseline, 36 of 38 participants were vitamin D sufficient (25OHD >50 nmol/L); at 12 mo, all participants were 25OHD sufficient. 25OHD did not differ between groups. WB and LS BMD significantly increased after 6 months of RT or JUMP and this increase was maintained at 12 mo; TH BMD increased only in RT. Osteocalcin increased significantly after 12 mo of RT or JUMP; CTx decreased significantly after 6 mo and returned to baseline concentrations at 12 mo in both RT and JUMP. Pain and fatigue ratings after RT or JUMP sessions were very low at 0, 6, and 12 mo.

conclusionRT or JUMP, which appeared safe and feasible, increased BMD of the whole body and lumbar spine, while RT also increased hip BMD, in moderately active, osteopenic men.

Indexed as

Absorptiometry, PhotonAdultBone DensityBone Diseases, MetabolicEnzyme-Linked Immunosorbent AssayExercise TherapyHumansMaleMiddle AgedOsteocalcinResistance TrainingOsteocalcinBone formationBone resorptionBone turnover markersExercise interventionMale osteopenia

Identifiers

PMID26092649
PMCPMC4503233
OpenAlexW2107749787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.