ArticleVeterinary research2015
Differences in intermittent and continuous fecal shedding patterns between natural and experimental Mycobacterium avium subspecies paratuberculosis infections in cattle.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- A Longitudinal Study ofAnimals : an open access journal from MDPI · 2026Article
- Evaluation of the Johne's disease surveillance program in dairy herds in Hokkaido, Japan, using a stochastic individual-based simulation model.The Journal of veterinary medical science · 2026Article
- Age-structured next generation matrix and RInfectious Disease Modelling · 2026Article
- Influence of landscape on the distribution of inflammatory bowel disease in England and Wales.BMC public health · 2026Article
- Pathological Features and Genotyping ofPathogens (Basel, Switzerland) · 2026Article
- Clinical insights on paratuberculosis in Arabian camels (Open veterinary journal · 2025Review
- Successful Control ofAnimals : an open access journal from MDPI · 2024Article
- Stage of infection withFrontiers in veterinary science · 2023Article
- Genomic epidemiology ofFrontiers in genetics · 2023Article
- Molecular and serological survey of paratuberculosis in cattle in selected districts of Western Uganda.BMC veterinary research · 2022Article
- Super Shedding in Enteric Pathogens: A Review.Microorganisms · 2022Review
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Modelling transmission of Mycobacterium avium subspecies paratuberculosis between Irish dairy cattle herds.Veterinary research · 2022Article
- Mycobacterium avium subspecies paratuberculosis infection in cattle - a review in the context of seasonal pasture-based dairy herds.Irish veterinary journal · 2022Review
- Modeling Paratuberculosis Transmission in a Small Dairy Herd Typical of Slovenia Suggests That Different Models Should Be Used to Study Disease Spread in Herds of Different Sizes.Animals : an open access journal from MDPI · 2022Article
- The source and fate of Mycobacterium tuberculosis complex in wastewater and possible routes of transmission.BMC public health · 2022Article
- Investigating effective testing strategies for the control of Johne's disease in western Canadian cow-calf herds using an agent-based simulation model.Frontiers in veterinary science · 2022Article
- Serological and Molecular Characterization ofAnimals : an open access journal from MDPI · 2021Article
- Article
- Characterizing infectious disease progression through discrete states using hidden Markov models.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this paper is to study shedding patterns of cows infected with Mycobacterium avium subsp. paratuberculosis (MAP). While multiple single farm studies of MAP dynamics were reported, there is not large scale meta-analysis of both natural and experimental infections. Large difference in shedding patterns between experimentally and naturally infected cows were observed. Experimental infections are thus probably driven by different pathological mechanisms. For further evaluations of shedding patterns only natural infections were used. Within such infections, the transition to high shedding was studied as a proxy to the development of a clinical disease. The majority of studied cows never developed high shedding levels. Those that do, typically never reduced their shedding level to low or no shedding. Cows that eventually became high shedders showed a pattern of continuous shedding. In contrast, cows with an intermittent shedding pattern had a low probability to ever become high shedders. In addition, cows that start shedding at a younger age (less than three years of age) have a lower hazard of becoming high shedders compared to cows starting to shed at an older age. These data suggest the presence of three categories of immune control. Cows that are intermittent shedders have the infection process under control (no progressive infection). Cows that start shedding persistently at a young age partially control the infection, but eventually will be high shedders (slow progressive infection), while cows that start shedding persistently at an older age cannot effectively control the infection and become high shedders rapidly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.