Evidence map›Paper›PMID 26092524›Full record

ReviewImmunology letters2015

The immune system as a self-centered network of lymphocytes.

Fabio R Santori

Abstract readReview
In one paragraph

Review in Immunology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Indispensable Role of Proteases in Plant Innate Immunity.International journal of molecular sciences · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Fabio R SantoriThe Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
New York University · US

Funding

RESEARCH IN THE PATHOGENESIS OF HEMATOLOGIC DISORDERST32HL007151 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AL-HOMSI, AHMAD SAMER · 1988 to 2018
$5.9M
NHLBI NIH HHS T32 HL007151NHLBI NIH HHS T32HL007151
6 · The paper itself

Abstract

This essay makes a brief historical and comparative review of selective and network theories of the immune system which is presented as a chemical sensory system with immune and non-immune functions. The ontogeny of immune networks is the result of both positive and negative selection of lymphocytes to self-epitopes that serve as a "template" for the recognition of foreign antigens. The development of immune networks progresses from single individual clones in early ontogeny into complex "information processing networks" in which lymphocytes are linked to inhibitory and stimulatory immune cells. The results of these regulatory interactions modulate immune responses and tolerance.

Indexed as

AnimalsAutoimmunityClonal EvolutionClonal Selection, Antigen-MediatedEpitopesHumansImmune SystemImmunityImmunomodulationLymphocytesSelf ToleranceEpitopesAutoimmunityB cellsImmune networksImmunologySelf-peptidesT cells

Identifiers

PMID26092524
PMCPMC4501489
OpenAlexW622640411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.