ArticleInternational journal of bipolar disorders2014
Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model.
Article in International journal of bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.Translational psychiatry · 2025Article
- Pushing the Frontiers: Optogenetics for Illuminating the Neural Pathophysiology of Bipolar Disorder.International journal of biological sciences · 2023Review
- Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior.Molecular psychiatry · 2021Article
- Circadian Rhythms of the Hypothalamus: From Function to Physiology.Clocks & sleep · 2021Review
- Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine DiScience · 2020Article
- Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.Molecular psychiatry · 2020Article
- Sex difference in the progression of manic symptoms during acute hospitalization: A prospective pilot study.Brain and behavior · 2020Article
- No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats.Psychiatry research · 2018Article
- Article
- Animal models for bipolar disorder: from bedside to the cage.International journal of bipolar disorders · 2017Review
- The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption.Behavioural brain research · 2017Article
- Article
- Predictive Validity of Some Common Animal Models of Bipolar Disorder Using Lithium and Lamotrigine Therapy: An Attempt towards a Battery-Based Approach for the Evaluation of Mood Stabilizers.Psychiatry investigation · 2016Article
- Sex differences in mania phenotype and ethanol consumption in the lateral hypothalamic kindled rat model.Translational psychiatry · 2015Article
- Partially empty sella with generalized epileptiform discharges presented as manic episode in an elderly female: A case with diagnostic dilemma - Causation or coincidence?Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The lateral hypothalamus integrates critical physiological functions such as the sleep-wake cycle, energy expenditure, and sexual behaviors. These functions are severely dysregulated during mania. In this study, we successfully induced manic-like behavioral phenotypes in adult, male Wistar rats through bilateral lateral hypothalamic area kindling (LHK). To test the validity of the model, we studied the effect of standard antimanic medications lithium (47.5 mg/kg) or valproic acid (200 mg/kg) twice/day for 15 days in attenuating manic-like behaviors in the LHK rat. Compared with pre-kindling behaviors, LHK rats displayed significantly increased sexual self-stimulation (P = 0.034), excessive rearing (P = 0.0005), feeding (P = 0.013), and grooming (P = 0.007) during the kindling interval. LHK rats also drank more alcohol during the mania-induction days compared with baseline ethanol consumption levels (P = 0.01). Moreover, LHK rat exhibited increased total locomotor activity (P = 0.02) with reduced rest interval (P < 0.001) during the mania induction and post-mania days compared with baseline activity levels and rest intervals. Chronic administration of lithium or valproic acid significantly attenuated manic-like behaviors in the LHK rat model. Given the behavioral phenotype and the response to standard antimanic medications, the LHK rats may provide a model for studying manic psychopathology in humans.
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Registered trials
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