Trial reportPsychopharmacology2015
Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers.
Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Dopamine D2-receptor blockade in humans disrupts the effect of effort on learning.PLoS biology · 2026Trial
- Individual differences in dopamine-related traits influence mood effects of dopamine D2-antagonist and antidepressant treatment expectations.The international journal of neuropsychopharmacology · 2025Trial
- Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Developing algorithmic psychiatry via multi-level spanning computational models.Cell reports. Medicine · 2025Review
- Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPREMBO reports · 2023Article
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- Decision-making inflexibility in a reversal learning task is associated with severity of problem gambling symptoms but not with a diagnosis of substance use disorder.BMC psychology · 2020Article
- DRD2 methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users.Addiction biology · 2020Article
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
- Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.Biological psychiatry · 2018Article
- Greater mindful eating practice is associated with better reversal learning.Scientific reports · 2018Article
- Distinct Response Inhibition Patterns in Obsessive Compulsive Disorder Patients and Pathological Gamblers.Frontiers in psychiatry · 2018Article
- Causal Learning in Gambling Disorder: Beyond the Illusion of Control.Journal of gambling studies · 2017Article
- Exploring the Relationship between Reward and Punishment Sensitivity and Gambling Disorder in a Clinical Sample: A Path Modeling Analysis.Journal of gambling studies · 2017Article
- The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.Neuroscience · 2017Review
- Validating molecular target-enriched fMRI for disentangling drug effects on dopamine.Imaging neuroscience (Cambridge, Mass.)Article
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePathological gambling has been associated with dopamine transmission abnormalities, in particular dopamine D2-receptor deficiency, and reversal learning deficits. Moreover, pervasive theoretical accounts suggest a key role for dopamine in reversal learning. However, there is no empirical evidence for a direct link between dopamine, reversal learning and pathological gambling.
objectiveThe aim of the present study is to triangulate dopamine, reversal learning, and pathological gambling.
methodsHere, we assess the hypothesis that pathological gambling is accompanied by dopamine-related problems with learning from reward and punishment by investigating effects of the dopamine D2-receptor antagonist sulpiride (400 mg) on reward- and punishment-based reversal learning in 18 pathological gamblers and 22 healthy controls, using a placebo-controlled, double-blind, counter-balanced design.
resultsIn line with previous studies, blockade of D2 receptors with sulpiride impaired reward versus punishment reversal learning in controls. By contrast, sulpiride did not have any outcome-specific effects in gamblers.
conclusionThese data demonstrate that pathological gambling is associated with a dopamine-related anomaly in reversal learning from reward and punishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.