ArticleJournal of the American Society for Mass Spectrometry2015
Infrared Spectroscopy of Mobility-Selected H+-Gly-Pro-Gly-Gly (GPGG).
Article in Journal of the American Society for Mass Spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Cryogenic Gas-phase IR Spectroscopy on a Commercial Ion Mobility-Mass Spectrometry Platform.Analytical chemistry · 2026Article
- How does the conformational landscape change on replacement in tetralin? A computational investigation with oxygen, sulfur, and selenium.Journal of molecular modeling · 2025Article
- A Direct Measurement of the Absolute Energies of Protonated Gly-Pro-Gly-Gly Conformations Using Ion Mobility Spectrometry and Guided Ion Beam Tandem Mass Spectrometry.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Surrogate Based Genetic Algorithm Method for Efficient Identification of Low-Energy Peptide Structures.Journal of chemical theory and computation · 2023Article
- Experimental techniques and terminology in gas-phase ion spectroscopy.Journal of mass spectrometry : JMS · 2022Review
- Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).Methods in molecular biology (Clifton, N.J.) · 2022Article
- Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers.ACS measurement science au · 2021Article
- Photoisomerization of Linear and Stacked Isomers of a Charged Styryl Dye: A Tandem Ion Mobility Study.Journal of the American Society for Mass Spectrometry · 2021Article
- Developments in tandem ion mobility mass spectrometry.Biochemical Society transactions · 2020Review
- Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy.Journal of the American Society for Mass Spectrometry · 2019Article
- Combining ultra-high resolution ion mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions.Faraday discussions · 2019Article
- Untangling Hydrogen Bond Networks with Ion Mobility Spectrometry and Quantum Chemical Calculations: A Case Study on HThe journal of physical chemistry. B · 2019Article
- In-depth structural analysis of glycans in the gas phase.Chemical science · 2019Review
- Monitoring the stabilities of a mixture of peptides by mass-spectrometry-based techniques.European journal of mass spectrometry (Chichester, England) · 2019Article
- New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells.The Analyst · 2019Review
- Operation and Performance of a Mass-Selective Cryogenic Linear Ion Trap.Journal of the American Society for Mass Spectrometry · 2018Article
- Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides.The Analyst · 2018Article
- Multiple solution structures of the disordered peptide indolicidin from IMS-MS analysis.International journal of mass spectrometry · 2018Article
- Infrared spectrum and structure of the homochiral serine octamer-dichloride complex.Nature chemistry · 2017Article
- Charge-state Resolved Infrared Multiple Photon Dissociation (IRMPD) Spectroscopy of Ubiquitin Ions in the Gas Phase.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report the first results from a new instrument capable of acquiring infrared spectra of mobility-selected ions. This demonstration involves using ion mobility to first separate the protonated peptide Gly-Pro-Gly-Gly (GPGG) into two conformational families with collisional cross-sections of 93.8 and 96.8 Å(2). After separation, each family is independently analyzed by acquiring the infrared predissociation spectrum of the H(2)-tagged molecules. The ion mobility and spectroscopic data combined with density functional theory (DFT) based molecular dynamics simulations confirm the presence of one major conformer per family, which arises from cis/trans isomerization about the proline residue. We induce isomerization between the two conformers by using collisional activation in the drift tube and monitor the evolution of the ion distribution with ion mobility and infrared spectroscopy. While the cis-proline species is the preferred gas-phase structure, its relative population is smaller than that of the trans-proline species in the initial ion mobility drift distribution. This suggests that a portion of the trans-proline ion population is kinetically trapped as a higher energy conformer and may retain structural elements from solution.
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Registered trials
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