ArticleScientific reports2015
Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Bacteria-Based Living Probes: Preparation and the Applications in Bioimaging and Diagnosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms.Nature communications · 2022Article
- Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin.Journal of biological engineering · 2021Review
- Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections.Nature communications · 2020Article
- Cardiovascular optoacoustics: From mice to men - A review.Photoacoustics · 2019Review
- Whole-Cell Photoacoustic Sensor Based on Pigment Relocalization.ACS sensors · 2019Article
- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.Light, science & applications · 2019Article
- Molecular Imaging in Synthetic Biology, and Synthetic Biology in Molecular Imaging.Molecular imaging and biology · 2017Review
- Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.Chemical Society reviews · 2017Review
- Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice.Light, science & applications · 2017Article
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Authors and funding
10 authors.
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Abstract
There is growing interest in genetically expressed reporters for in vivo studies of bacterial colonization in the context of infectious disease research, studies of the bacterial microbiome or cancer imaging and treatment. To empower non-invasive high-resolution bacterial tracking with deep tissue penetration, we herein use the genetically controlled biosynthesis of the deep-purple pigment Violacein as a photobleaching-resistant chromophore label for in vivo optoacoustic (photoacoustic) imaging in the near-infrared range. We demonstrate that Violacein-producing bacteria can be imaged with high contrast-to-noise in strongly vascularized xenografted murine tumors and further observe that Violacein shows anti-tumoral activity. Our experiments thus identify Violacein as a robust bacterial label for non-invasive optoacoustic imaging with high potential for basic research and future theranostic applications in bacterial tumor targeting.
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